Gengigel/Gengigel Prof

Gengigel/Gengigel Prof

Manufacturer:

Ricerfarma

Distributor:

Pharmaniaga Manufacturing Berhad
Full Prescribing Info
Contents
Hyaluronic acid.
Description
Gengigel/Gengigel Prof is a medical device containing high molecular weight (HMW) hyaluronic acid (in the form of sodium hyaluronate) with high level of purity. Its formulation is specifically created in order to resemble that of the hyaluronic acid found in normal gingival tissue.
Action
Pharmacology: Gengigel/Gengigel Prof is a long acting HMW hyaluronic acid, which, when applied, provides periodontal tissue/fluid balance with accelerated healing and repair functions by preventing the deficiency of natural gingival HMW hyaluronic acid and enhancing its effects.
Hyaluronic acid is a naturally occurring physiological constituent of connective tissue (especially in the gingival mucosa), where it performs anti-oedematous and tissue repair functions and does not develop any local or systemic pharmacological effect upon the mucosa.
Hyaluronic acid is extensively depolymerized and reduced to its basic subunit constituents by plaque bacterial enzyme action. The physico-chemical and macro-aggregating properties of hyaluronic acid helps to explain its anti-inflammatory properties. It is found in connective tissue throughout the body in a selective and specific manner. It is particularly concentrated in the outmost layers of healthy gingival tissue where it contributes to both the barrier function and tensile strength of the periodontal ligament. The presence of HMW hyaluronic acid is essential for the maintenance of the healthy gingival tissue.
In periodontal disease and other tissue traumas (inflammatory conditions, gingival pockets, wounds), the tissue requirement for hyaluronic acid increases considerably (by up to some 200% compared with the basal values); thus, demonstrating its specific role in regulating cell turnover and optimizing local tissue regeneration.
The deficiency in hyaluronic acid that arises under these conditions prevents the tissue from the following: Restoring the normal free water balance (as a consequence of which swelling and compression causes an increase in pain); activating the migration of fibrocytes (cells contributing to tissue healing) and as a consequence healing is delayed. Therefore, the lack of suitable HMW hyaluronic acid is responsible for the continuation of the inflammatory condition.
Studies in man show that the availability of exogenous hyaluronic acid of similar characteristics to that of the naturally occurring component helps to facilitate the natural tissue healing and recovery process.
Gengigel/Gengigel Prof provides maximum adhesion and thus, allows hyaluronic acid (which would otherwise be eliminated by constant salivary drainage) to remain in situ.
Indications/Uses
Inflammatory conditions (gingivitis, gingival bleeding, gingival retraction, gingival pockets) and other traumatic conditions (in particular mouth ulcers, wounds caused by removable prostheses or orthodontic appliances, cleaning, abrasions, tooth extractions, post-surgical recovery, etc), and those disease conditions where the gingival mucosa requires increased concentrations of hyaluronic acid.
Dosage/Direction for Use
Gengigel Oral Gel: Apply a film onto the gingival tissue, massage gently with clean fingers to aid its correct distribution on the mucosal surface.
Gengigel Hydrogel Mouthrinse: Rinse with 10 mL (1 dose) for 1-2 min. The compound is ready for use; do not dilute.
Gengigel Oromucosal Spray: 1-2 puffs on the inflamed or traumatized tissue. Keep the bottle vertical. Any puff guarantees a homogenous and constant distribution of liquid on the mouth surface.
Gengigel Prof Fluid: Rinse with 10 mL for 1-2 min. Do not dilute.
Gengigel Prof Oral Gel: Apply 1 mL deep into the gingival pockets.
Administration: After correct oral hygiene, apply Gengigel 3-5 times daily (after main meals) for 3-4 weeks, continuing until all symptoms have disappeared. It is advisable not to eat or drink for at least 30 min after application. Harmless if swallowed.
Contraindications
Known hypersensitivity to any of the excipients of Gengigel/Gengigel Prof. Do not use in surgical wounds.
Special Precautions
Gengigel/Gengigel Prof is extremely safe, presenting no contraindications or side-effects and can be used without restriction by children, pregnant woman and the elderly. Its safety profile is particularly useful when anti-inflammatories are contraindicated. By virtue of the properties of xylitol, a natural sweetener that does not promote tooth decay or cause significant variations in the blood sugar level; thus, Gengigel/Gengigel Prof is also suitable for diabetics.
Drug Interactions
As it does not have any known drug interactions, Gengigel/Gengigel Prof may be used safely during specific therapies (eg, with antibiotics).
Storage
Store at a temperature of 5°-40°C.
MIMS Class
Preparations for Oral Ulceration & Inflammation
ATC Classification
D03AX05 - hyaluronic acid ; Belongs to the class of other cicatrizants. Used in the treatment of wounds and ulcers.
Presentation/Packing
Form
Gengigel hydrogel mouthrinse 0.025 % HA
Packing/Price
150 mL x 1's
Form
Gengigel oral gel 0.2 % HA
Packing/Price
1 mL x 1's;20 mL x 1's
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/malaysia/image/info/gengigel oral gel 0-2 percent ha/20 ml?id=7819774d-d6c7-4d7d-9cbd-a80900e80c7e
Form
Gengigel Prof syringe 0.8 % HA
Packing/Price
1 mL x 4 × 1's
Form
Gengigel Prof fluid 0.1 % HA
Packing/Price
500 mL x 1's
Form
Gengigel oromucosal spray 0.01 % HA
Packing/Price
20 mL x 1's
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