Glencet-M

Glencet-M

Manufacturer:

Glenmark Pharma

Distributor:

Uni Drug House
Concise Prescribing Info
Contents
Levocetirizine diHCl 5 mg, montelukast Na 10 mg
Indications/Uses
Symptomatic relief of seasonal allergic rhinitis.
Dosage/Direction for Use
Adult ≥18 yr 1 tab once daily. Moderate renal impairment 1 tab once every 2 days, severe renal impairment 1 tab once every 3 days.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to levocetirizine diHCl, montelukast Na, cetirizine, hydroxyzine or any other piperazine derivatives. Galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption. Severe renal impairment CrCl <10 mL/min.
Special Precautions
Patients w/ predisposing factors of urinary retention eg, spinal cord lesion, prostatic hyperplasia; epilepsy, at risk of convulsion. Neuropsychiatric events, eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, neuropathy. Allow 3-day wash-out period prior to allergy skin tests. Avoid aspirin or NSAIDs in patients w/ known aspirin sensitivity. Concurrent use w/ alcohol. May affect ability to drive & use machines. Moderate to severe renal impairment. Pregnancy & lactation. Not recommended in paed & adolescents <18 yr.
Adverse Reactions
Upper resp infection. Diarrhoea, nausea, vomiting; elevated ALT, AST levels; rash; pyrexia; headache, somnolence, dry mouth, fatigue.
Drug Interactions
Decreased montelukast AUC w/ phenobarb, phenytoin, rifampicin. Increased montelukast exposure w/ gemfibrozil. Small decreased clearance of cetirizine w/ theophylline. Increased exposure to cetirizine w/ ritonavir. Decreased rate of absorption w/ food. Additional reduced alertness & performance impairment w/ alcohol or other CNS depressants.
MIMS Class
Antihistamines & Antiallergics
ATC Classification
R03DC53 - montelukast, combinations ; Belongs to the class of leukotriene receptor antagonists. Used in the systemic treatment of obstructive airway diseases.
Presentation/Packing
Form
Glencet-M FC tab
Packing/Price
14's
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