Glibenclamide - oral

Patient Medicine Information
Why do I need this medicine?
Glibenclamide is used to treat type 2 diabetes (long-term condition in which the body gradually becomes resistant to the effects of insulin or the pancreas does not produce enough insulin).

This medicine helps treat your diabetes by keeping your blood sugar in control.

Glibenclamide is meant to be taken as part of a complete diabetes care programme that should include exercise, a healthy diet and regular monitoring of blood sugar levels.
How do I take this medicine?
Take Glibenclamide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine should be taken with breakfast or with the first main meal. Try to take it at the same time each day.

Glibenclamide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and return to the normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Glibenclamide if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to similar sulfonylureas or sulfonamides such as glimepiride, sulfasalazine, or sulfamethoxazole.

Alert your doctor if you have the following conditions:
  • other type of diabetes called type 1 diabetes
  • severe infection
  • porphyria (a rare blood disorder)
  • severe kidney disease
  • severe liver disease
as this medicine may not be suitable for you.

Do not give this medicine to elderly above 70 years old unless instructed to do so by the doctor.

Do not take Glibenclamide with bosentan (medicine for high blood pressure in the lungs).
What should I take note of while taking this medicine?
Inform your doctor if you have an inherited condition known as G6PD deficiency or any severe infection, trauma, or any severe conditions where blood sugar control may be difficult.

Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving this medicine to those who are malnourished or debilitated (a person who is physically or mentally weak usually due to illness or old age). Malnourished and debilitated people may be more sensitive to the side effects.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking Glibenclamide.

Certain gene deficiencies in the enzyme G6PD may cause serious side effects from this medicine. Individuals who have the A-Haplotype 202A/376G (rs1050828 and rs1050829) and the Mediterranean 563T (rs5030868) variants may have an increased risk of developing haemolytic anaemia (a type of anaemia where red blood cells are prematurely destroyed). Although not routinely done, your doctor may advise you to undergo genetic testing to check if this medicine is best suited for you. If you know you have this gene type, inform your doctor.

For as long as you are taking Glibenclamide, you may need to have regular urine and blood tests to check your body’s response to the medicine. Your doctor will advise you about how often you need to have urine and blood tests.

If you are using this medicine, you may have been warned about hypoglycaemia (low blood sugar).

How do I know if I am experiencing hypoglycaemia?

Hypoglycaemia is the medical term for low blood sugar. Symptoms of hypoglycaemia include dizziness, tremor, shaky hands, feeling hungry, weak or confused, sweating. These signs are your body’s way of warning you that your blood sugar level is low.

It is important to recognise these symptoms and get relief for hypoglycaemia quickly, as the hypoglycaemia may worsen.

What should I do if I am experiencing hypoglycaemia?

Always carry some glucose tablets (also known as dextrose tablets) with you. Take 15 grams of glucose tablet at first sign of hypoglycaemia, wait for 15 minutes and re-check your blood sugar level. If you are not feeling better or if your blood sugar level is still low (less than 4 mmol/L or 70 mg/dL), take another 15 grams of glucose tablet.

If you don’t have glucose tablets, you may take any of the following:
  • 1/2 cup (120 mL) of juice or regular soda (not diet)
  • 1 tablespoon of sugar, honey, or corn syrup
  • hard candies, jellybeans, or gumdrops (not sugar-free)
Get medical help should symptoms did not improve after second serving.
What side effects could I experience?
Glibenclamide may cause hypoglycaemia (low blood sugar) and reduced alertness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: blurred vision, nausea, vomiting, indigestion, heartburn, metallic taste, tooth discolouration, sensitivity to sunlight, and weight gain.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Glibenclamide with bosentan (medicine for high blood pressure in the lungs).

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for high blood pressure e.g. captopril, enalapril, propranolol
  • medicines for irregular heartbeat e.g. disopyramide, quinidine
  • medicine to treat TB (infection known as tuberculosis) e.g. rifampicin, isoniazid
  • medicines for fungal infections e.g. miconazole, fluconazole
  • medicines for mood disorders e.g. chlorpromazine, lithium
  • water pills or medicines for water retention e.g. furosemide, hydrochlorothiazide
  • certain antibiotics e.g. ciprofloxacin, chloramphenicol, clarithromycin, co-trimoxazole, doxycycline
  • blood-thinning medicine e.g. warfarin
  • cholesterol-lowering medicines e.g. colesevelam, clofibrate
  • stomach medicines e.g. cimetidine, ranitidine
  • ciclosporin (medicine used in organ transplant or certain immune disorders)
This list does not include all medicines that may interact with Glibenclamide.

Inform your doctor if you are currently taking birth control pills as this can reduce the effectiveness of this medicine. You should not stop or start any birth control pills without first informing your doctor. Ask your doctor about using non-hormonal birth control as an alternative while being treated with Glibenclamide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

It is important for you to maintain a healthy diet and weight in order to help keep your diabetes under control.

It may be helpful to discuss your diet plan with your doctor or dietitian to manage your weight and blood sugar levels.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from light and moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on glibenclamide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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