Concise Prescribing Info
Metformin HCl
Type 2 DM when not adequately controlled by dietary management & exercise alone. Monotherapy or in combination w/ other oral antidiabetic agents or w/ insulin.
Dosage/Direction for Use
Adult Monotherapy & combination w/ other oral antidiabetic agents Initially 1 tab bd-tds, adjust dose after 10-15 days according to blood glucose measurements. Max: 3 g daily. Combination w/ insulin Initially 1 tab bd-tds, adjust insulin according to blood glucose measurements. Childn & adolescent from 10 yr Monotherapy & combination w/ insulin 500 or 850 mg once daily, adjust dose after 10-15 days according to blood glucose measurements. Max: 2 g daily in 2-3 divided doses.
Should be taken with food.
Hypersensitivity. Diabetic ketoacidosis, diabetic pre-coma. Acute conditions w/ potential to alter renal function eg, dehydration, severe infection, shock, intravascular administration of iodinated contrast agents. Acute or chronic disease which may cause tissue hypoxia eg, cardiac or resp failure, recent MI, acute alcohol intoxication, alcoholism. Any acute metabolic acidosis. Renal failure or dysfunction (CrCl <60 mL/min) & hepatic insufficiency. Lactation.
Special Precautions
Discontinue use if dehydration occurs or if metabolic acidosis is suspected. Lactic acidosis; risk factors for lactic acidosis eg, inadequately controlled diabetes, ketosis, prolonged fasting, any conditions associated w/ hypoxia. Discontinue prior to, during & after 48 hr of iodinated contrast agent administration; 48 hr prior to elective surgery w/ general anaesth. Determine serum creatinine levels prior to & regularly thereafter. Perform usual laboratory tests for diabetes monitoring. Concomitant use w/ antihypertensives, diuretics, NSAIDs; insulin of sulfonyureas. Excessive alcohol intake, hepatic insufficiency. Renal impairment. Pregnancy & lactation. Childn 10-12 yr. Elderly.
Adverse Reactions
Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite; metallic taste.
Drug Interactions
Increased risk of lactic acidosis w/ alcohol. Renal failure, metformin accumulation, risk of lactic acidosis w/ iodinated contrast agents. Intrinsic hyperglycaemic activity of glucocorticoids, β2-agonists, diuretics. Decreased blood glucose levels w/ ACE inhibitors.
MIMS Class
ATC Classification
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
Glucon film-coated tab 500 mg
10 × 10's;50 × 10's
Glucon film-coated tab 850 mg
10 × 10's
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