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Glucophage

Glucophage

metformin

Manufacturer:

Merck

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Metformin HCl
Indications/Uses
Monotherapy or in combination w/ other oral antidiabetic agents or w/ insulin for type 2 DM in adults when dietary management & exercise alone does not result in adequate glycaemic control. In childn >10 yr & adolescents, may be used as monotherapy or in combination w/ insulin. Reduction of diabetic complications in overwt type 2 diabetic adults treated w/ metformin as 1st-line therapy after diet failure.
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Dosage/Direction for Use
Adult w/ normal renal function (GFR ≥90 mL/min) Monotherapy & combination w/ other oral antidiabetic agents Initially 500- or 850 mg bd-tds, adjusted based on blood glucose measurements after 10-15 days. Max: 3 g daily in 3 divided doses. Transfer from another oral antidiabetic agent Discontinue the other agent & initiate as indicated. Combination w/ insulin Initially 500- or 850 mg bd-tds, adjust insulin dose based on blood glucose measurements. Childn & adolescent Monotherapy & combination w/ insulin Initially 500- or 850 mg once daily, adjusted based on blood glucose measurements after 10-15 days. Max: 2 g daily in 2 or 3 divided doses. Patient w/ renal impairment (GFR 60-89 mL/min) Max: 3,000 mg daily in 2-3 divided dose, (GFR 45-59 mL/min) Max: 2,000 mg daily in 2-3 divided dose, (GFR 30-44 mL/min) Max: 1,000 mg daily in 2-3 divided doses.
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Overdosage
View Glucophage overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: Take during or after meals.
Contraindications
Hypersensitivity. Any type of acute metabolic acidosis eg, lactic acidosis, diabetic ketoacidosis. Diabetic pre-coma. Acute conditions w/ potential to alter renal function eg, dehydration, severe infection, shock. Disease which may cause tissue hypoxia eg, decompensated heart or resp failure, recent MI. Acute alcohol intoxication, alcoholism. Severely reduced renal function (GFR <30 mL/min), hepatic insufficiency.
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Special Precautions
Discontinue use 48 hr prior to & at the time of surgery w/ general, spinal or epidural anaesthesia; intravascular administration of iodinated contrast agents. Increased risk of lactic acidosis. Regularly monitor use in patients w/ stable chronic heart failure. Overwt patients should continue energy-restricted diet. Combination w/ insulin or other oral antidiabetics. Monitor renal function & temporarily discontinue use in presence of conditions that alter renal function. Pregnancy. Not recommended during lactation. Childn & adolescents. Elderly.
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Adverse Reactions
GI disorders eg, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite. Taste disturbance.
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Drug Interactions
Increased risk of lactic acidosis w/ alcohol intoxication; NSAIDs including selective COX-2 inhibitors, ACE inhibitors, AIIA, diuretics especially loop diuretics. Reduced efficacy w/ organic cation transporters (OCT)1 inhibitors eg, verapamil. Increased GI absorption & efficacy w/ OCT1 inducers eg, rifampicin. Increased plasma conc w/ OCT2 inhibitors eg, cimetidine, dolutegravir, ranolazine, trimethoprim, vandetanib, isavuconazole. Altered efficacy & renal elimination w/ OCT1 & OCT2 inhibitors eg, crizotinib, olaparib. Iodinated contrast agents. Drugs w/ intrinsic hyperglycaemic activity eg, systemic & local glucocorticoids, sympathomimetics.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Glucophage detailed prescribing information
Storage
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Description
View Glucophage description for details of the chemical structure and excipients (inactive components).
Action
View Glucophage mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
Presentation/Packing
Form
Glucophage FC tab 1000 mg
Packing/Price
8 × 15's
Form
Glucophage FC tab 500 mg
Packing/Price
6 × 20's
Form
Glucophage FC tab 850 mg
Packing/Price
5 × 20's
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