Duopharma (M)


Duopharma Marketing
Concise Prescribing Info
Metformin HCl
Monotherapy or adjunct to sulfonylurea for NIDDM when hyperglycemia cannot be controlled by diet management, exercise or wt reduction.
Dosage/Direction for Use
Adult 500 mg tds, may be gradually increased if needed to max: 3 g daily.
Should be taken with food.
Hypersensitivity. Acute metabolic acidosis eg, lactic acidosis, diabetic ketoacidosis; conditions needing blood glucose control eg, severe burns, dehydration, diabetic coma, hyperosmolar nonketotic coma, severe infection, major surgery, severe trauma; shock, pulmonary insufficiency, alcoholism; conditions associated w/ hypoxaemia eg, cardioresp insufficiency, CV collapse, CHF, acute MI. Not be given in patients undergoing diagnostic or medical exam using contrast media eg, angiography, pyelography. Severe renal impairment (GFR <30 mL/min); severe hepatic disease.
Special Precautions
Conditions decreasing/delaying stomach emptying eg, diarrhea, gastroparesis, intestinal obstruction, vomiting or conditions causing delayed food absorption; conditions predisposing to hyperglycemia (eg, female hormonal changes, high fever) or hypoglycemia (eg, adrenal insufficiency, debilitated physical conditions, malnutrition); hyperthyroidism; lactic acidosis; inadequately controlled diabetes, ketosis; conditions associated w/ hypoxia. Monitor glucose levels frequently; monitor urine for presence of glucose & ketones if blood glucose levels >200 mg/dL; monitor HbA1c every 3 mth. Determine serum folic acid & vit B12 conc every 1-2 yr during long-term therapy. Assess GFR prior to & at least annually thereafter. Concomitant use w/ drugs impairing renal function eg, antihypertensives, diuretics, NSAIDs; drugs causing lactic acidosis. Prolonged fasting. Excessive alcohol intake. Renal & hepatic insufficiency. Pregnancy & lactation. Ped patients.
Adverse Reactions
Anorexia, dyspepsia, flatulence, headache, metallic taste, nausea, vomiting, wt loss.
Drug Interactions
Increased risk of developing hypoglycemia w/ alcohol. Increased plasma conc w/ cimetidine; other cationic drugs excreted by renal tubular transport eg, amiloride, Ca-channel blockers, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin. Hyperglycaemia w/ OCs, corticosteroids, diuretics, estrogens, INH, nicotinic acid, phenothiazines, phenytoin, sympathomimetics, thyroid hormones. Hypoglycaemia w/ clofibrate, MAOIs, probenecid, propranolol, rifabutin, rifampicin, salicylates, sulfonamides, sulphonylureas.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
Glucoxit tab 500 mg
10 × 10's;100 × 10's
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