Initially 500 mg tds or 750 mg bd. Max: 3 g daily.
Should be taken with food.
Heart failure, dehydration, acute or chronic alcoholism, or any other condition likely to predispose lactic acidosis. IDDM, ketoacidosis, severe infection, stress, trauma. Conditions associated w/ hypoxaemia. Hepatic or renal impairment. Pregnancy.
Discontinue therapy 2-3 days before surgery & reinstate after regaining control of renal function. Elderly.