Initially 500 mg tds or 750 mg bd. Max: 3 g daily.
Should be taken with food.
Heart failure, dehydration, acute or chronic alcoholism or any other condition predisposing lactic acidosis. IDDM, ketoacidosis, severe infection, stress, trauma. Conditions associated w/ hypoxaemia. Hepatic or renal impairment. Pregnancy.
Discontinue therapy 2-3 days before surgery & reinstate after regaining renal function control. Elderly.