Hypersensitivity to metformin hydrochloride or to any of the excipients of Glumet XR.
Diabetic ketoacidosis or diabetic precoma; renal failure or renal dysfunction [creatinine clearance (CrCl) <60 mL/min]; acute conditions with the potential to alter renal function eg, dehydration, severe infection, shock and intravascular administration of iodinated contrast agents; acute or chronic disease which may cause tissue hypoxia eg, cardiac or respiratory failure, recent myocardial infarction and shock; hepatic insufficiency, acute alcohol intoxication, alcoholism.
Use in lactation: Metformin is excreted into human breast milk. No adverse effects were observed in breastfed newborns/infants. However, as only limited data are available, breastfeeding is not recommended during metformin treatment. A decision on whether to discontinue breastfeeding should be made, taking into account the benefit of breastfeeding and the potential risk to adverse effect on the child.