Monotherapy and Combination with Other Oral Antidiabetics: Usual Starting Dose: 1 tab daily with the evening meal.
After 10-15 days, the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability.
Maximum Recommended Dose: Glumet XR 500 mg: 4 tabs of Glumet XR 500 mg daily.
Dosage increases should be made in increments of 500 mg every 10-15 days, up to a maximum of 2000 mg once daily with the evening meal.
Glumet 750 mg:2 tabs of Glumet XR 750 mg once daily with the evening meal.
In patients already treated with metformin tablets, the starting dose of Glumet XR should be equivalent to the daily dose of metformin immediate-release tablets.
If transfer from another oral antidiabetic agent is intended, discontinue the other agent and initiate Glumet XR at the dose indicated previously.
Combination with Insulin: Metformin and insulin may be used in combination therapy to achieve better blood glucose control. The usual starting dose of Glumet XR is 1 tab of 500 mg once daily with the evening meal, while insulin dosage is adjusted on the basis of blood glucose measurements.