Listed in Dosage.
Dosage/Direction for Use
Adult : PO Cough For tickly dry cough: As 15% v/v syr: 10 mL 3-4 times/day. Rectal Constipation As supp: 2-3 g once daily as needed. Topical Hydrate and soften skin As 25% or 40% cream: Apply regularly to affected areas.
Adult: For dry tickly cough: As 15% v/v syr: 5-10 mL 3-4 times daily.
Child: As 15% v/v syr: 3 months to <1 year 5 mL 3-4 times daily; 1-5 years Same as adult dose.
Adult: As supp: 2-3 g once daily as needed.
Child: 2-<6 years 1-1.2 g once daily as needed; ≥6 years 2-2.1 g once daily as needed.
Hydrate and soften skin
Adult: As 25% or 40% w/w cream: Apply regularly to affected areas.
Child: Same as adult dose.
Forms explosive mixture with strong oxidising agent. May result in black discolouration when combined with zinc oxide or bismuth subnitrate.
Patient with hypervolaemia, cardiac failure, renal disease, dehydration, diabetes mellitus. Treatment with a cough medicine in children (especially under 1 year old) should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation.
Cardiac disorders: Cardiac arrhythmia, circulatory overload, heart failure.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, thirst, abdominal cramp, rectal irritation/discomfort, tenesmus, rectal mucosal erosion.
General disorders and administration site conditions: Application site reaction (e.g. burning sensation, erythema, pain, pruritus, rash, irritation).
Metabolism and nutrition disorders: Hyperglycaemia, dehydration.
Musculoskeletal and connective tissue disorders: Rectal tenesmus.
Nervous system disorders: Dizziness, headache (oral).
Psychiatric disorders: Mental confusion.
Renal and urinary disorders: Glycosuria.
Respiratory, thoracic and mediastinal disorders: Severe pulmonary oedema.
Skin and subcutaneous tissue disorders: Exacerbation of eczema and dry skin.
Symptoms: Headache, thirst, nausea, vomiting, hyperglycaemia, dehydration, diarrhoea, dizziness, mental confusion and cardiac arrhythmia. Management: Symptomatic and supportive treatment. Perform gastric lavage for recent ingestion.
Description: Glycerol is an osmotic dehydrating agent with hygroscopic and lubricating properties which increases plasma osmolality, resulting in the movement of water from extravascular spaces into the plasma through osmosis. It has a demulcent property which possibly blocks sensory cough receptors in the respiratory tract.
Absorption: Readily absorbed from the gastrointestinal tract (oral). Poorly absorbed (rectal).
Metabolism: Extensively metabolised in the liver into glucose or glycogen or oxidised to carbon dioxide and water.
Excretion: Mainly via urine, as unchanged drug.
Store below 25°C. Protect rectal suppository from heat.
A06AG04 - glycerol ; Belongs to the class of enemas. Used in the treatment of constipation.
A06AX01 - glycerol ; Belongs to the class of other laxatives.