Glycine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Irrigation
Irrigant during transurethral prostatic or bladder surgery

Adult: As 1.5% sterile solution: Use as required according to the nature and duration of the procedure, and discretion of the surgeon. Administer via transurethral instillation with appropriate urologic instrumentation.

Contraindications

Anuria.

Special Precautions

Patient with severe cardiopulmonary dysfunction. Hepatic and severe renal impairment. Not indicated for injection by usual parenteral routes.

Adverse Reactions

Significant: If systemically absorbed: Fluid and electrolyte disorders (e.g. acidosis, electrolyte loss, marked diuresis, urinary retention, oedema, dehydration, hyponatraemia), CV disorders (e.g. hypotension, tachycardia, angina-like pain, thrombophlebitis), pulmonary disorders (e.g. pulmonary congestion), hyperammonaemia (in patients with hepatic impairment), coma (immediate or delayed).
Ear and labyrinth disorders: Vertigo.
Eye disorders: Visual disturbances, transient blindness.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea.
General disorders and administration site conditions: Chills.
Nervous system disorders: Convulsions.

Pregnancy Category (US FDA)

Irrigation/Urethral: C

Monitoring Parameters

Determine CV status prior to and during transurethral resection of the prostate (particularly in patients with cardiac disease). Monitoring of fluid and electrolyte levels may be considered.

Action

Description: Glycine is an amino acid and nonelectrolyte. Glycine 1.5% solution in water is nontoxic, nonhaemolytic and nonconductive with a refractive index near to that of water which makes it suitable as a urologic irrigating fluid during electrosurgical procedures. It is sufficient to minimise the risk of intravascular haemolysis that may occur from the absorption of plain water through open prostatic veins during transurethral resection.
Pharmacokinetics:
Metabolism: If systemically absorbed: Primarily metabolised via transamination to serine, and via deamination to ammonia which is usually converted to urea.
Excretion: Via the kidneys (if systemically absorbed).

Chemical Structure

Storage

Store between 20-25°C. Do not freeze. Protect from excessive heat.

MIMS Class

Intravenous & Other Sterile Solutions

ATC Classification

B05CX03 - glycine ; Belongs to the class of other solutions used as irrigating solutions.

References

Buckingham R (ed). Glycine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/02/2021.

Glycine Irrigant (B. Braun Medical Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/02/2021.

Glycine Irrigant (Hospira, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/02/2021.

Joint Formulary Committee. Glycine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/02/2021.

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