Dexa Medica


Averroes Pharma
Concise Prescribing Info
Granisetron HCl
Prevention & treatment of acute & delayed nausea & vomiting associated w/ chemo- & radiotherapy (CINV & RINV); post-op nausea & vomiting (PONV).
Dosage/Direction for Use
Adult CINV 1-3 mg slow IV inj over 30 sec or IV infusion over 5 min prior to chemotherapy. Max: 9 mg/24 hr. RINV prevention 1-3 mg slow IV inj over 30 sec or as IV infusion over 5 min prior to radiotherapy. PONV prevention 1 mg slow IV inj over 30 sec prior to anesth induction. PONV treatment 1 mg slow IV inj over 30 sec. Max: 3 mg daily. Childn CINV 10-40 mcg/kg IV infusion over 5 min prior to chemotherapy, may administer additional dose w/in 24 hr at least 10 min after initial infusion.
Special Precautions
Signs of subacute intestinal obstruction; preexisting arrhythmias or cardiac conduction disorders; cardiac comorbidities. Patients on cardiotoxic chemotherapy &/or w/ concomitant electrolyte abnormalities. Cross-sensitivity w/ other 5-HT3 antagonists. Concomitant use w/ other serotonergic drugs. Pregnancy & lactation.
Adverse Reactions
Headache; constipation. Elevated hepatic transaminases.
Drug Interactions
Increased total plasma clearance w/ phenobarb. Serotonin syndrome w/ other serotonergic drugs. Concurrent use w/ drugs prolonging QT interval &/or are arrhythmogenic.
MIMS Class
Antiemetics / Supportive Care Therapy
ATC Classification
A04AA02 - granisetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
Granodex soln for inj/infusion 1 mg/mL
1 mL x 5 × 1's;3 mL x 5 × 1's
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