Human albumin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV Acute hypovolaemic shock Initial: 25 g, adjust according to response. Usual rate: Up to 5 mL/min using 5% soln. Hypoproteinaemia Up to 2 g/kg/day. Usual rate: Up to 5 mL/min using 5% soln.
Dosage Details
Intravenous
Neonatal hyperbilirubinaemia
Child: 1 g/kg of albumin before exchange transfusion. Usual rates of infusion: Up to 5 ml/minute (5% solution) or 1-2 ml/minute (20% solution).

Intravenous
Hypoproteinaemia
Adult: Up to 2 g/kg daily. Usual rates of infusion: Up to 5 ml/minute (5% solution) or 1-2 ml/minute (20% solution).

Intravenous
Acute hypovolaemic shock
Adult: Initially, 25 g of albumin, adjusted according to patient's response. Usual rates of infusion: Up to 5 ml/minute (5% solution) or 1-2 ml/minute (20% solution).
Child: Up to 1 g/kg, adjusted according to patient's response. Usual rates of infusion: Up to 5 ml/minute (5% solution) or 1-2 ml/minute (20% solution).
Incompatibility
Dilution with water will produce a hypo-osmolar solution that may cause severe haemolysis and renal failure. Y-site admin: Midazolam, vancomycin, verapamil. Admixture: Verapamil.
Contraindications
Cardiac failure, severe anaemia, history of hypersensitivity, parenteral nutrition.
Special Precautions
Hypertension or low cardiac reserve; additional fluids for dehydrated patients. Monitor for signs of cardiac overload in injured or postoperative patients. May carry risk of viral transmission. Volume admin and rate of infusion must always be individualised according to situation and response. Pregnancy, lactation.
Adverse Reactions
Allergic reactions, nausea, vomiting, increased salivation, fever and chills; vascular overload, haemodilution and pulmonary oedema.
Potentially Fatal: Anaphylactic shock.
IV/Parenteral: C
Drug Interactions
Albumin solution should not be mixed by protein hydrolysates or alcoholic solutions. Risk of atypical reactions to ACE inhibitors in patients undergoing therapeutic plasma exchange with albumin human replacement.
Lab Interference
False elevations of serum alkaline phosphatase concentrations may occur.
Action
Description: Human albumin increases intravascular oncotic pressure and causes movement of fluids from interstitial into intravascular space. Human albumin solutions are available in various concentrations. Solutions containing 5% human albumin are usually used in hypovolemic patients, whereas more concentrated 25% solutions are recommended in patients in whom fluid and sodium intake must be minimised e.g. patients with hypoproteinaemia or cerebral oedema or in paediatric patients.
Storage
Store below 30°C. Do not freeze.
Disclaimer: This information is independently developed by MIMS based on Human albumin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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