Accord Healthcare
Concise Prescribing Info
Dexmedetomidine HCl
Sedation of initially intubated & mechanically ventilated patients during treatment in ICU. Sedation of non-intubated patients prior to &/or during surgical & other procedures.
Dosage/Direction for Use
Adult ICU sedation Loading infusion: 1 mcg/kg IV infusion over 10 min. Maintenance infusion: 0.2-0.7 mcg/kg/hr. Procedural sedation Loading infusion: 1 mcg/kg IV infusion over 10 min. Less invasive procedures eg, ophth surgery Loading infusion: 0.5 mcg/kg IV infusion over 10 min. Maintenance infusion: Initially 0.6 mcg/kg/hr, titrated to 0.2-1 mcg/kg/hr. Awake fiberoptic intubation patient Loading infusion: 1 mcg/kg IV infusion over 10 min. Maintenance infusion: 0.7 mcg/kg/hr until endotracheal tube is secured. Patient >65 yr Loading infusion: 1 mcg/kg IV infusion over 10 min.
Hypersensitivity. Advanced heart block (grade 2 or 3) unless paced; uncontrolled HTN; acute cerebrovascular conditions.
Special Precautions
Not to be given as bolus dose. Not to be used as general anaesth induction agent. Not suitable in patients requiring continuous deep sedation. Not recommended for patient-controlled sedation; malignant hyperthermia-sensitive patients. Severe CV instability; preexisting bradycardia; hypotension, hypovolaemia, chronic hypotension or reduced functional reserve; impaired peripheral autonomic activity; ischaemic heart disease or severe cerebrovascular disease; severe neurological disorders. Monitor respiration in non-intubated patients. Transient HTN during loading dose. Concomitant use w/ other substances w/ sedative or CV actions; spinal or epidural anesth; benzodiazepines, opioids, alcohol. Avoid abrupt discontinuation. May affect ability to drive & use machines. Hepatic or renal impairment. Not recommended in women of childbearing potential not using contraception & during pregnancy. Lactation. Elderly >65 yr.
Adverse Reactions
Bradycardia; hypotension, HTN. Hyper-, hypoglycaemia; agitation; myocardial ischaemia or infarction, tachycardia; resp depression; nausea, vomiting, dry mouth; w/drawal syndrome, hyperthermia.
Drug Interactions
Enhanced effects w/ anaesth, sedatives, hypnotics, opioids. Enhanced hypotensive & bradycardic effects w/ β-blockers.
ATC Classification
N05CM18 - dexmedetomidine ; Belongs to the class of other hypnotics and sedatives.
Hydex infusion conc 100 mcg/mL
2 mL x 1's
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