Hydrocortisone + Miconazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Infected dermatitis As oint containing hydrocortisone 1% and miconazole 2%: Apply to the affected area bid to tid up to approx 7 days, when inflammation have disappeared. Tinea pedis; Candidal intertrigo As cream containing hydrocortisone 1% and miconazole 2%: Apply to affected area bid. Max treatment duration: 7 days.
Dosage Details
Topical/Cutaneous
Infected dermatitis
Adult: As oint containing hydrocortisone 1% and miconazole 2%: Apply to the affected area bid to tid. Rub gently until absorbed by the skin. Once inflammation have disappeared (after approx 7 days), continue treatment w/ miconazole nitrate 20 mg/g cream or powd.
Child: Same as adult dose.

Topical/Cutaneous
Candidal intertrigo, Tinea pedis
Adult: As cream containing hydrocortisone 1% and miconazole 2%: Apply to affected area bid. Rub gently until absorbed by the skin. Max treatment duration: 7 days.
Child: ≥10 yr Same as adult dose.
Contraindications
Hypersensitivity to hydrocortisone or miconazole. Tubercular or viral infections of the skin or those caused by gm-ve bacteria.
Special Precautions
Childn.
Adverse Reactions
Severe hypersensitivity reactions, including anaphylaxis and angioedema; skin irritation, burning sensation, urticaria, pruritus, rash, contact dermatitis, erythema, skin inflammation, skin hypopigmentation; adrenal suppression, irritability.
Patient Counseling Information
This drug may damage latex contraceptive agents (e.g. condoms or diaphragms).
Drug Interactions
May increase the effect of oral anticoagulants (e.g. warfarin).
Action
Description: Hydrocortisone is an anti-inflammatory steroid which exerts its action through reduction in the vascular component of the inflammatory response, suppression of migration of polymorphonuclear leukocytes, and reversal of increased capillary permeability; it also has a vasoconstrictive action. Miconazole is a potent broad-spectrum antifungal and antibacterial agent w/ marked activity against dermatophytes, pathogenic yeasts and many gm+ve bacteria.
Pharmacokinetics:
Absorption: Hydrocortisone: Absorbed after topical application (approx 3%). Miconazole: Remains in the skin for up to 4 days after topical application. Bioavailability: <1%.
Distribution: Hydrocortisone: Plasma protein binding: >90%. Miconazole: Plasma protein binding: 88.2%; also bound to RBC (10.6%).
Metabolism: Hydrocortisone: Undergoes metabolism in the liver and tissues.
Excretion: Hydrocortisone: Via urine, as metabolites (mostly glucuronides), w/ small amounts as unchanged drug. Half-life: Approx 100 min. Miconazole: Mainly via faeces and small amounts in urine, as unchanged drug and metabolites.
Chemical Structure

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Storage
Store at or below 25°C.
Disclaimer: This information is independently developed by MIMS based on Hydrocortisone + Miconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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