Soft tissue inflammation
Adult: As Na phosphate or Na succinate esters: 100-200 mg as local inj.
Intra-articular
Joint inflammations
Adult: As acetate: 5-50 mg depending on size of affected joint.
Intravenous
Supplement in adrenal insufficiency during minor surgery under general anaesthesia
Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. 25-50 mg at induction. Resume with usual oral corticosteroid after surgery.
Intravenous
Supplement in adrenal insufficiency during moderate or major surgery
Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. Usual oral corticosteroid dose on the morning of the surgery followed by 25-50 mg at induction, then similar doses of hydrocortisone tid for 24 hr after moderate surgery or 48-72 hr after major surgery. Resume oral therapy once injections are stopped.
Intravenous
Acute adrenocortical insufficiency
Adult: 100-500 mg 3-4 times/24 hr according to the severity of the condition and patient response. Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower.
Child: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg. Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower.
Child: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg. Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower.
Oral
Replacement therapy in adrenocortical insufficiency
Adult: 20-30 mg daily in 2 divided doses.
Child: 400-800 mcg/kg/day, in 2-3 divided doses.
Child: 400-800 mcg/kg/day, in 2-3 divided doses.
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1-2.5 % cream/ointment/lotion: Apply thinly onto affected area(s) once daily - bid.