Hydroflumethiazide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Oedema 50-100 mg/day. Max: 200 mg/day. HTN Initial: 12.5 mg/day. Usual: 25-50 mg/day.
Dosage Details
Oral
Oedema
Adult: 50-100 mg daily in 1-2 divided doses, may reduce to 25-50 mg on alternate days or intermittently. Max: 200 mg daily.

Oral
Hypertension
Adult: Initial dose: 12.5 mg daily. Usual dose: 25-50 mg daily alone or in conjunction with other antihypertensives.
Child: 1 mg/kg daily, may reduce dose for maintenance.
Contraindications
Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia. Pregnancy and lactation.
Special Precautions
Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients taking antidiabetics.
Adverse Reactions
Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
Overdosage
Lethargy, nausea, weakness and electrolyte imbalance, possibly progress to coma within a few hr with minimal depression of respiratory and CV function and with no evidence of dehydration or serum electrolyte changes. GI irritation and hypermotility, temporary elevation of the BUN, serum electrolyte changes (e.g. hypokalemia, hypochloremia, hyponatremia) may occur in renally impaired patients. Empty stomach by inducing vomiting with ipecac syrup If patient is conscious. Cathartics should not be admin as they may promote loss of fluid and electrolytes. Supportive and symptomatic treatment with monitoring of serum electrolytes, renal, respiratory, and CV function. Replace fluid and electrolytes where necessary.
Drug Interactions
Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; Allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
Action
Description: Hydroflumethiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of sodium and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Onset: 2 hr.
Duration: 24 hr.
Pharmacokinetics:
Absorption: Incompletely but fairly rapidly absorbed from the GI tract.
Excretion: Excreted in the urine.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Hydroflumethiazide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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