Hydroxyethyl starch


Concise Prescribing Info
Indications/Uses
As a plasma volume expander in hypovolaemic shock.
Dosage/Direction for Use
Adult : IV As 6%, 10% solution: Initially, 10-20 mL via slow infusion. Dose titration and rate of infusion are based on patient’s condition and colloid requirement. Max time interval: 24 hours. Max daily dose: 18 mL/kg.
Dosage Details
Intravenous
Plasma volume expander in hypovolaemic shock
Adult: As 6%, 10% solution: Initially, 10-20 mL via slow infusion and with careful monitoring of adverse events. Dose titration and rate of infusion are based on patient’s condition and colloid requirement. Max time interval: 24 hours. Max daily dose: 18 mL/kg.
Renal Impairment
Contraindicated.
Hepatic Impairment
Severe: Contraindicated.
Contraindications
Hypersensitivity, critically ill patients, sepsis, burns, oliguria or anuria not related to hypovolaemia, undergoing dialysis, pulmonary oedema, CHF, severe hypernatraemia, severe hyperchloremia, pre-existing coagulation or bleeding disorders, intracranial bleeding, organ transplant patients. Renal and severe hepatic impairment.
Special Precautions
Patient with risk factors of overexpansion of blood volume (e.g. pulmonary and circulatory problems). Patient undergoing cardiopulmonary bypass. Mild to moderate hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Anaphylactoid reactions (e.g. bradycardia, tachycardia, bronchospasm), bleeding, fluid overload, haemodilution.
Blood and lymphatic system disorders: Anaemia.
Injury, poisoning and procedural complications: Wound haemorrhage.
Investigations: Increased coagulation time, decreased clotting factors, decreased haematocrit, prolonged prothrombin time, increased serum amylase.
Skin and subcutaneous tissue disorders: Pruritus, skin rash.
MonitoringParameters
Monitor blood pressure, heart rate, capillary refill time, cardiac index, haemoglobin, coagulation parameters, renal function, serum electrolyte, LFT, urine output, acid-base balance at baseline and periodically during treatment.
Overdosage
Symptoms: Fluid overload with resulting cardiac and pulmonary failure. Management: Supportive treatment. Administer diuretics as required.
Lab Interference
May cause elevated serum amylase and interfere with pancreatitis diagnosis.
Action
Description: Hydroxyethyl starch is a colloidal solution which expands the plasma volume. It consists of amylopectin, a glucose polymer. The glucose units of the polymer are being replaced by hydroxyethyl groups, thus reducing the degradation of amylopectin by α-amylase in the body.
Synonym: HES, tetrastarch.
Duration: ≥6 hours.
Pharmacokinetics:
Distribution: Volume of distribution: 5.9 L.
Metabolism: Molecule >50,000 daltons are metabolised by plasma α-amylase.
Excretion: Via urine (small molecules <50,000 daltons as unchanged drug and metabolites).
Chemical Structure

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Storage
Store between 15-25°C. Do not freeze.
ATC Classification
B05AA07 - hydroxyethylstarch ; Belongs to the class of blood substitutes and plasma protein fractions. Used as blood substitutes.
Disclaimer: This information is independently developed by MIMS based on Hydroxyethyl starch from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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