Icatibant: Indication, Dosage, Side Effect, Precaution

Concise Prescribing Info

Indications/Uses

Hereditary angioedema.

Dosage/Direction for Use

Adult : SC Patient w/ C1-esterase inhibitor deficiency: 30 mg as a single dose during acute attack. May repeat dose 6 hrly if response is inadequate or symptoms recur. Max: 90 mg/day.

Dosage Details

Subcutaneous
Hereditary angioedema

Adult: Patient w/ C1-esterase inhibitor deficiency: 30 mg as a single dose during acute attack. May repeat dose 6 hrly if response is inadequate or symptoms recur. Max: 90 mg daily.

Special Precautions

Patient w/ acute ischaemic heart disease, unstable angina pectoris, history or recently had a stroke.

Adverse Reactions

Significant: Airway obstruction.
Nervous: Dizziness, headache.
GI: Nausea.
Hepatic: Increased serum transaminase.
Dermatologic: Rash, erythema, pruritus.
Others: Pyrexia, inj site reaction (e.g. burning, swelling, itching, warm sensation, pain).

Pregnancy Category (US FDA)

SC: C

Patient Counseling Information

This drug may cause dizziness, if affected, do not drive or operate machinery.

MonitoringParameters

Monitor symptom relief; laryngeal symptoms or airway obstruction.

Drug Interactions

Decreased antihypertensive effect of ACE inhibitors.

Action

Description: Icatibant, a selective bradykinin antagonist, inhibits bradykinin from binding B2 receptor which causes vasodilation, localised swelling, inflammation and acute pain and thereby relieves the symptoms of acute attack.
Onset: 50% decrease in symptoms: Approx 2 hr.
Duration: Approx 6 hr.
Pharmacokinetics:
Absorption: Bioavailability: Approx 97%. Time to peak plasma concentration: 0.75 hr.
Distribution: Volume of distribution: 20-25 L. Plasma protein binding: 44%.
Metabolism: Extensively metabolised by proteolytic enzymes to inactive metabolites.
Excretion: Mainly via urine, <10% as unchanged drug. Elimination half-life 1-1.8 hr.

Chemical Structure

Storage

Store between 2-25°C. Follow applicable procedures for receiving, handling, admin, and disposal. Wear gloves during receiving, unpacking, and placing in storage.

MIMS Class

Other Cardiovascular Drugs

ATC Classification

B06AC02 - icatibant ; Belong to the class of drugs used in the treatment of hereditary angioedema.

References

Anon. Icatibant. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/12/2017.

Buckingham R (ed). Icatibant Acetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/12/2017.

Firazyr Injection, Solution (Shire US Manufacturing Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/12/2017.

Joint Formulary Committee. Icatibant. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/12/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Icatibant Acetate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/12/2017.

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