Adult and children nasal drops: Adverse events from clinical trial data are both infrequent and based on small patient exposure. Accordingly, events reported from extensive post-marketing experience at therapeutic/recommended dose and considered attributable are listed below. As most undesirable effects are based on post-marketing spontaneous reporting, precise frequency estimation is not possible.
Respiratory, thoracic and mediastinal disorders: nasal discomfort (burning of the nasal mucosa), nasal dryness, sneezing (especially in sensitive patients), after the effect has worn off increased swelling of the mucosa (reactive hyperaemia) & epistaxis.
Nervous system disorders: somnolence, sedation, headache, hallucinations (especially in children) & convulsions (especially in children).
Cardiac disorders: palpitations & tachycardia.
Vascular disorders: hypertension.
Immune system disorders: hypersensitivity reactions (angioedema, rash, pruritus).
Psychiatric disorders: insomnia & restlessness.
General disorders and administration site conditions: fatigue & tachyphylaxis (associated with long-term use or overdose).
Infant nasal drops: In especially sensitive patients, it might results in respiratory, thoracic and mediastinal disorder such as nasal discomfort (burning of nasal mucosa) or nasal dryness, or sneezing may occasionally occur. In rare cases after the effect has worn off - an intense sensation of "blocked" nose (reactive hyperaemia), epistaxis, and apnoea in newborns and in young infants (especially in case of overdosage).
With topical intranasal use, overdosage leads rarely to occasionally to systemic sympathomimetic effects like palpitations, accelerated pulse (tachycardia) and increase in blood pressure. Restlessness, insomnia, tiredness and headaches, somnolence, sedation, headache, hallucinations and convulsions (especially in children), hypersensitivity reactions (angioedema, rash, pruritus), tachyphylaxis (associated with long-term use or overdose) have been observed in very rare cases.