NEW
Imfinzi

Imfinzi

Manufacturer:

AstraZeneca

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Durvalumab
Indications/Uses
Patients w/ unresectable stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following platinum-based chemo- & radiation therapy. In combination w/ etoposide & either carboplatin or cisplatin for 1st-line treatment of patients w/ extensive-stage small cell lung cancer (ES-SCLC).
Dosage/Direction for Use
NSCLC 10 mg/kg IV infusion over 60 min every 2 wk until disease progression, unacceptable toxicity or max period: 12 mth. ES-SCLC 1,500 mg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 4 cycles, followed by 1,500 mg every 4 wk as monotherapy until disease progression or unacceptable toxicity. Patient ≤30 kg 20 mg/kg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 4 cycles, followed by 20 mg/kg every 4 wk as monotherapy until wt increase to >30 kg.
Special Precautions
Monitor patients for signs & symptoms of pneumonitis, hepatitis, diarrhea or colitis, rash, infection, infusion-related reactions. Endocrinopathies eg, thyroid disorders, adrenal insufficiency, type 1 DM & hypophysitis/hypopituitarism; other severe & fatal immune-related ARs. Monitor abnormal renal function tests prior to & periodically during treatment. Women of childbearing potential should use effective contraception during & at least 3 mth after last dose. Pregnancy. Not to be used during lactation. Ped patients.
Adverse Reactions
Pneumonitis/radiation pneumonitis, hepatitis, colitis, endocrinopathies, nephritis, dermatologic reactions, other immune-mediated reactions, infection, infusion-related reactions. Fatigue/asthenia. NSCLC: Cough, upper resp tract infection, dyspnea, rash. SCLC: Nausea, alopecia.
ATC Classification
L01XC28 - durvalumab ; Belongs to the class of monoclonal antibodies, other antineoplastic agents. Used in the treatment of cancer.
Presentation/Packing
Form
Imfinzi concentrate for soln for infusion 120 mg/2.4 mL
Packing/Price
1's
Form
Imfinzi concentrate for soln for infusion 500 mg/10 mL
Packing/Price
1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in