Hypersensitivity to sulphonamides. Not to be used prophylactically. Not indicated for management of hemiplegic, basilar or ophthalmoplegic migraine. Not to be given in patients w/ CAD. Potentially serious neurological conditions eg, CVA, TIA. Controlled HTN; serotonin syndrome eg, altered mental status, autonomic instability & neuromuscular abnormalities; history of seizures or other risk factors lowering seizure threshold. May exacerbate headache due to medication overuse. Not recommended w/ co-administration of any triptan or 5-HT1
agonist. Concomitant use w/ SSRI & SNRIs. May affect ability to drive & use machines. Hepatic & renal impairment. Not to be given in postmenopausal women, males >40 yr. Pregnancy & lactation. Childn & adolescents <18 yr. Not recommended in elderly >65 yr.