Inderal

Inderal Dosage/Direction for Use

propranolol

Manufacturer:

AstraZeneca

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
Since the half-life may be increased in patients with significant hepatic or renal impairment, caution must be exercised when starting treatment and selecting the initial dose.
Adults: Hypertension: A starting dose of 80 mg twice a day may be increased at weekly intervals according to response. The usual dose range is 160-320 mg per day and the maximum daily dose must not exceed 640 mg per day (see table). With concurrent diuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.
Angina, anxiety, migraine and essential tremor: A starting dose of 40 mg two or three times daily may be increased by the same amount at weekly intervals according to patient response. An adequate response in anxiety, migraine and essential tremor is usually seen in the range.
80-160 mg/day, and in angina in the range 120-240 mg/day. A maximum daily dose of 240 mg for migraine and 480 mg for angina must not be exceeded (see table).
Arrhythmias, anxiety tachycardia, hypertrophic obstructive cardiomyopathy and thyrotoxicosis: A dosage range of 10-40 mg three or four times a day usually achieves the required response. A maximum daily dose of 240 mg for arrhythmias must not be exceeded. (See table.)
Post-myocardial infarction: Treatment should start between days 5 and 21 after myocardial infarction, with an initial dose of 40 mg four times a day for 2 or 3 days. In order to improve compliance the total daily dosage may thereafter be given as 80 mg twice a day (see table).
Phaeochromocytoma: (Inderal is to be used only in the presence of effective alpha-blockade). Preoperative: 60 mg daily for three days is recommended. Non-operable malignant cases: 30 mg daily (see table).

Click on icon to see table/diagram/image

Elderly: Evidence concerning the relation between blood level and age is conflicting. With regard to the elderly, the optimum dose should be individually determined according to clinical response.
Children: Dosage should be individually determined and the following is only a guide: Arrhythmias, phaeochromocytoma, thyrotoxicosis: 0.25 - 0.5 mg/kg three or four times daily as required.
Migraine: Under the age of 12: 20 mg two or three times daily. Over the age of 12: the adult dose.
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