Indinavir is used together with other medicines for viral infections in the treatment of Human Immunodeficiency Virus (HIV) infection.
This medicine is not a cure for HIV infection. It only helps to keep the virus in check and can help improve the quality of life. It does not prevent the spread of HIV to other people.
Take Indinavir exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
This medicine should be taken with water,1 hour before or 2 hours after meals. Make sure to drink at least 1.5 liters of liquid throughout the day to ensure adequate hydration.
You may take Indinavir with food if you are also taking ritonavir (other medicine to treat HIV).
Indinavir must be taken regularly for it to be effective. Continue to take this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Do not skip any doses. You must complete the entire course of medicine. If you don't, the infection will not be properly controlled.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you ever had an allergic reaction (breathlessness, rashes, swollen eyes) to similar antiviral medications.
Do not take Indinavir with medicines for sleep disorder, heart disease, high cholesterol levels, migraine, stomach, allergy and mood disorder. If you are taking Indinavir together with ritonavir, do not take them with medicines for mood disorder, pain, urinary problems, heart disease, anxiety, sleep disorders, and skin infections. Please see section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have the following:
- liver disease
- kidney disease
- blood disorder
Let your doctor know if you are pregnant or breastfeeding.
Do not breastfeed while being treated with Indinavir. If you have HIV, it is best that you do not breastfeed as HIV passes into the breast milk. Avoid breastfeeding in order to reduce the risk of passing HIV to your baby. It is recommended to give your baby commercial infant formula provided that you have access to clean water and facilities.
This medicine is not a cure for HIV. It only helps to slow down the development of HIV infection.
Indinavir does not reduce your risk of passing the HIV infection to others through sexual contact or through contamination with infected blood. Ensure that you use proper precautions to avoid spreading HIV to others.
This medicine may weaken your immune system, leaving you more vulnerable to infections. Avoid crowded places and people who are sick to minimise the risk of catching an infection. Always keep your doctor updated on your condition and go for your appointed check-ups.
While being treated with Indinavir, you will need to have regular blood tests. These blood tests help your doctor to monitor your condition and the health of your liver. Your doctor will advise you about how often you will need to have these blood tests.
Indinavir may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects may include any of the following: nausea, vomiting, diarrhoea, stomach pain, wind, dry mouth, headache, dry skin, rashes, itching, and tiredness.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- pain or discomfort on your upper abdomen or back, blood in urine
- yellowing of the eyes or skin
- rashes with skin peeling or blisters
- fever with persistent sore throat or mouth ulcers, unusual bleeding or bruising
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Indinavir with the following medicines:
- medicines for sleep disorder e.g. midazolam, alprazolam, triazolam
- medicines for heart disease e.g. amiodarone
- medicines for high cholesterol levels e.g. lovastatin, simvastatin
- medicines for migraine e.g. ergotamine, ergometrine
- medicines for stomach e.g. cisapride
- medicines for allergy e.g. terfinadine, astemizole
- medicines for mood disorder e.g. pimozide, quetiapine
- medicines for tuberculosis (TB) e.g. rifampicin
- St. John's wort (herbal medicine)
If you are taking Indinavir together with ritonavir, do not take them with the following medicines
- medicines for mood disorder e.g. clozapine
- medicines for pain e.g. piroxicam, meperidine
- medicines for urinary problems e.g. alfuzosin
- medicines for heart disease e.g. quinidine, flecainide, encainide, propafenone
- medicines for anxiety and sleep disorders e.g. clorazepate, diazepam, estazolam, flurazepam
- fusidic acid (topical antibiotic)
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines to treat viral infections e.g. delavirdine
- medicines for high blood pressure e.g. nifedipine, felodipine
- medicines for epilepsy (seizures or fits) e.g. phenytoin, carbamazepine
- medicines for fungal infections e.g. ketoconazole, itraconazole
- medicines for impotence or sexual dysfunction e.g. sildenafil
- medicines for TB e.g. rifabutin
- warfarin (blood-thinning medicine)
This list does not include all medicines that may interact with Indinavir.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.