Indobufen


Concise Prescribing Info
Indications/Uses
Thromboembolic disorders.
Dosage/Direction for Use
Adult : PO 200-400 mg/day in 2 divided doses.
Dosage Details
Oral
Thromboembolic disorders
Adult: 200-400 mg/day in 2 divided doses. May also be given parenterally using the sodium salt.
Elderly: >65 yr: 100-200 mg/day.
Renal Impairment
100-200 mg/day.
Contraindications
GI ulceration, ulcerative colitis, active bleeding, haemophilia.
Special Precautions
Pregnancy, lactation.
Adverse Reactions
Haemostatic disorders, GI disturbances (diarrhoea, ulcer, bleeding).
Drug Interactions
Reduced absorption with antacids and cholestyramine.
Action
Description: Indobufen inhibits platelet aggregation by reversibly inhibiting the cyclo-oxygenase enzyme, resulting in suppressed thromboxane synthesis.
Pharmacokinetics:
Absorption: Rapidly absorbed; peak plasma concentrations in 2 hr.
Distribution: Protein-binding: 99%.
Metabolism: Hepatic.
Excretion: Via urine (75%, as metabolites and unchanged drug); 8 hr (plasma half-life).
Disclaimer: This information is independently developed by MIMS based on Indobufen from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in