Discontinue use if neuroleptic malignant syndrome or tardive dyskinesia/extrapyramidal symptoms occur. History of cardiac arrhythmias, congenital long QT syndrome; hyperglycemia & DM; wt gain; known CV or cerebrovascular disease or conditions predisposing to hypotension; seizures or conditions lowering seizure threshold; preexisting severe GI narrowing or dysphagia or significant difficulty in swallowing; clinically significant low WBC or drug-induced leukopenia/neutropenia; risk factors for venous thromboembolism; Parkinson's disease & dementia w/ Lewy bodies; priapism. Intraoperative floppy iris syndrome. Antiemetic effect. Conditions that contribute to core body temp elevation or dehydration. Concomitant use w/ risperidone; psychostimulants eg, methylphenidate; drugs prolonging QT interval. May affect ability to drive & use machines. Severe hepatic impairment. Pregnancy. Not to be used during lactation. Adolescents & childn <12 yr w/ schizophrenia; adolescents & childn <18 yr w/ schizoaffective disorder. Elderly w/ dementia.