Infections and Infestations: Not known: Herpetic keratitis.
Eye Disorders: Very common: Increased iris pigmentation; mild to moderate conjunctival hyperaemia eye irritation (burning grittiness, itching, stinging and foreign body sensation); eyelash and vellus hair changes (increased length, thickness, pigmentation and number) (vast majority of reports in Japanese population). Common: transient punctate epithelial erosions, mostly without symptoms; blepharitis; eye pain. Uncommon: Eyelid oedema: dry eye; keratitus; vision blurred; conjunctivitis. Rare: Iritis/uveitis (the majority of reports in patients with concomitant predisposing factors); macular oedema; symptomatic corneal oedema and erosions; periorbital oedema; misdirected eyelashes sometimes resulting in eye irritation; extra row of cilia at the aperture of the meibomian glands (distichiasis). Not known: iris cyst.
Nervous System Disorders: Not known: Headache, Dizziness.
Cardiac Disorders: Very rare: Aggravation of angina in patients with pre-existing disease. Not known: Palpitations.
Respiratory, Thoracic and Mediastinal Disorders: Rare: Asthma, asthma exacerbation and dyspnoea.
Skin and Subcutaneous Tissue Disorders: Uncommon: Skin rash. Rare: Localised skin reaction on the eyelids; darkening of the palpebral skin of the eyelids.
Musculoskeletal and Connective Tissue Disorders: Not known: Myalgia; Arthralgia.
General Disorders and Administration Site Conditions: Very rare: Chest pain.