Concise Prescribing Info
Timolol maleate
Elevated IOP in patients w/ ocular HTN or open-angle glaucoma.
Dosage/Direction for Use
Instill 1 drop bd in affected eye(s). When used w/ another topical β-blocking agent Discontinue use after full day therapy & start 1 drop bd of 0.25% on the next day. May be increased to 1 drop bd of 0.5% in affected eye(s). Transferring from single anti-glaucoma agent other than topical β-blocking agent Continue agent & add 1 drop bd of 0.25% in affected eye(s). Discontinue previous agent on the following day & continue 0.5% therapy.
Hypersensitivity. Bronchial asthma or history of bronchial asthma or severe COPD; sinus bradycardia; 2nd or 3rd degree AV block; overt cardiac failure; cardiogenic shock.
Special Precautions
Cardiac failure; mild & moderate COPD (eg, bronchitis, emphysema), bronchospastic disease; spontaneous hypoglycemia or diabetic patients especially those w/ labile diabetes. Thyrotoxicosis. May mask signs of hyperthyroidism. Avoid abrupt w/drawal. Pregnancy & lactation.
Adverse Reactions
Local irritation. Ocular irritation, burning & stinging sensation, conjunctivitis, blepharitis, keratitis, blepharoptosis, decreased corneal sensitivity, diplopia, ptosis; bradycardia, arrhythmia, CHF, hypotension, syncope, heart block, CVA, cerebral ischemia, palpitation, dyspnea, nasal congestion, cough bronchospasm, resp failure; headache, depression, dizziness, paresthesia, asthenia, diarrhoea, nausea.
Drug Interactions
Additive effects w/ cathecolamine-depleting drugs eg, reserpine. Additive effects in prolonging AV conduction time w/ digitalis & Ca antagonists. Additive β-blockade effects w/ β-adrenergic blockers. Concomitant use of 2 topical β-adrenergic blocking agents.
ATC Classification
S01ED01 - timolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Iotim eye drops 0.5% w/v
5 mL x 1's
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