Iron dextran


Concise Prescribing Info
Indications/Uses
Fe-deficiency anaemia.
Dosage/Direction for Use
Adult : IV/IM As a preparation containing 50 mg elemental Fe/mL. Test dose: 0.5 mL; observe patient for at least 1 hr for signs for hypersensitivity. Total dose (ml) = 0.0442 (desired haemoglobin - observed haemoglobin) x LBW + (0.26 x LBW) (Note: LBW = Lean body weight(kg)) Usual max: 100 mg/day. Total dose may be given in divided doses on a daily or twice wkly basis via IM inj; may also be given IV by total-dose infusion or as divided inj.
Dosage Details
Parenteral
Iron-deficiency anaemia
Adult: As a preparation containing the equivalent of 50 mg/ml of iron. Total dose (ml) = 0.0442 (desired haemoglobin - observed haemoglobin) x LBW + (0.26 x LBW) (Note: LBW = Lean body weight(kg)) A test dose of 0.5 ml should be given and observe patient for at least 1 hr for signs for hypersensitivity. Usual daily max: 2 ml (100 mg). Total dose may be given in divided doses on a daily or twice wkly basis via IM inj (into the upper outer quadrant of the buttock); may also be given intravenously by total-dose infusion or as divided inj.
Child: As a preparation containing the equivalent of 50 mg/ml of iron. Total dose (ml) = 0.0442 (desired haemoglobin - observed haemoglobin) x LBW + (0.26 x LBW) (Note: LBW = Lean body weight(kg)) A test dose (<10 kg: 0.2 ml; 10-20 kg: 0.3 ml) should be given and observe the patient for at least 1 hr for signs of hypersensitivity. Usual daily max: <5 kg: Up to 0.5 ml (25 mg); 5-9 kg: Up to 1 ml (50 mg); larger children: 2 ml (100 mg). Total dose may be given in divided doses on a daily or twice wkly basis via IM inj (into the upper outer quadrant of the buttock); may also be given intravenously by total-dose infusion or as divided inj.
Reconstitution
Solutions for infusion should be diluted in normal saline.
Contraindications
Anaemia that are not due to iron deficiency; haemochromatosis; haemolytic anemia. Severe liver damage or acute kidney infection. Lactation.
Special Precautions
History of allergies or asthma. Pre-existing CV disease, hepatic impairment. May worsen rheumatoid arthritis. Not recommended in children <4 mth. Admin of oral iron salts should be ceased before giving parenteral iron. Rapid IV admin may cause vascular flushing and hypotension. Pregnancy.
Adverse Reactions
Adverse effects may be delayed 24-48 hr after IV admin or 3-4 days after IM admin. Flushing, dizziness, fever, chills, nausea, headache, diaphoresis. Chest pain or tightness, shock, MI, hypertension, tachycardia, bradycardia and arrhythmias. Local reactions, pain and staining may occur at the site of inj after IM inj.
Potentially Fatal: Severe anaphylactoid reactions.
IM/IV/Parenteral: C
Drug Interactions
Reduced effect when used with chloramphenicol.
Action
Description: Iron dextran is used for the treatment of iron-deficiency anaemia where oral therapy is ineffective or impracticable. Released iron replaces the depleted iron stores in the bone marrow where it is used in the synthesis of haemoglobin.
Pharmacokinetics:
Absorption: IM admin: Absorbed mainly through the lymphatic system. IV admin: Taken up by cells of the reticuloendothelial system; especially in the liver and spleen.
Excretion: Urine and feces via reticuloendothelial system.
Disclaimer: This information is independently developed by MIMS based on Iron dextran from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Iron Dextran Weimer
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