Iron polymaltose


Concise Prescribing Info
Indications/Uses
Fe-deficiency anaemia.
Dosage/Direction for Use
Adult : PO Doses equivalent to 100 mg elemental Fe/day, up to 300 mg/day. IV As inj containing 100 mg elemental Fe/2 mL: Total dose of Fe needed (mg): Wt (kg) x (normal Hb - actual Hb in g/L) x 0.24 + Fe depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥34 kg. Refer to product insert for dosage table. IM As inj containing 100 mg elemental Fe/2 mL: Total dose of Fe needed (mg): Wt (kg) x (normal Hg- actual Hg in g/L) x 0.24 + Fe depot. Fe depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥34 kg. Max single daily dose: >10-45 kg: 2 mL; >45 kg: 4 mL.
Dosage Details
Intramuscular
Iron-deficiency anaemia
Adult: As inj containing 100 mg iron as iron polymaltose/2 ml: Admin by ventro-gluteal inj according to Hochstetter method (refer to package insert for details). Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥34 kg. May give dose as alternate day inj of 2 ml (or 4 ml at longer interval) until total dose is reached. Max single daily dose: >10-45 kg: 2 ml; >45 kg: 4 ml.
Child: As inj containing 100 mg iron as iron polymaltose/2 ml: Admin by ventro-gluteal inj according to Hochstetter method (refer to package insert for details).Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Max single daily dose: >10-45 kg: 2 ml; 5-10 kg: 1 ml; infants (up to 5 kg): 0.5 ml.

Intravenous
Iron-deficiency anaemia
Adult: As inj containing 100 mg iron as iron polymaltose/2 ml: Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Refer to product insert for dosage table. 1st 50 ml to be infused slowly (5-10 drops/minute) and observe patient closely. If well tolerated, increase rate to 30 drops/minute (based on drop volume of 0.067ml).
Child: As inj containing 100 mg iron as iron polymaltose/2 ml: Total dose of iron needed (mg): Wt (kg) x (normal haemoglobin - actual haemoglobin in g/L) x 0.24 + iron depot. Iron depot calculated as 15 mg/kg up to a wt of about 34 kg, max of 500 mg for body wt ≥ 34 kg. Refer to product insert for dosage table. 1st 50 ml to be infused slowly (5-10 drops/minute) and observe patient closely. If well tolerated, increase rate to 30 drops/minute (based on drop volume of 0.067ml).

Oral
Iron-deficiency anaemia
Adult: As chewable tablet/syrup/drops: Doses equivalent to 100 mg of elemental iron daily, up to 300 mg daily.
Reconstitution
Intravenous:
IV infusion: Total dose to be admin to be added to 500 ml of normal saline (max 2500 mg in 500 ml).
Incompatibility
Intramuscular:
Do not mix with acidic substance or substances with a strong reducing effect.
Intravenous:
Do not mix with acidic substance or substances with a strong reducing effect.
Contraindications
Hypersensitivity or intolerance to iron and overloading of iron in the body. Anaemia not caused by iron deficiency. Disturbances in iron utilisation, thalassemia. Patients receiving repeated blood transfusion. Parenteral: Iron overload, Ostler-Rendu-Weber syndrome, chronic polyarthritis, bronchial asthma, inflammation or infection of kidney or liver, uncontrolled hyperparathyroidism, decompensated liver cirrhosis. Pregnancy (1st trimester).
Special Precautions
Avoid concomitant parenteral and oral iron admin, oral iron therapy should start at least 1 wk after last iron inj. Parenteral: Pregnancy (2nd and 3rd trimester), allergies, hepatic and liver insufficiency, low iron binding capacity and or folic acid deficiency. Facilities for CPR should be available during admin. Excessive IV infusion rate may cause nausea and epigastric upset. IV infusion route should be used only if IM route is unacceptable and when there is no stored iron in the bone marrow.
Adverse Reactions
GI irritation, epigastric pain, stomach cramping, constipation, nausea, vomiting, diarrhoea, dark stools, heart burn, discoloured urine, teeth staining. IM: pain at inj site, abdominal pain at lower quadrant and local inflammation with inguinal lymphadenopathy. IV: Joint and muscle pain, bronchospasm, hypotension, tachycardia, flushing, sweating, dizziness.
Potentially Fatal: Parenteral: Anaphylactoid reactions, circulatory collapse.
Drug Interactions
Concurrent use with psychotropic drugs may worsen constipation. Increased systemic side effects with concomitant ACE inhibitors and parenteral iron admin.
Action
Description: Iron polymaltose is a water soluble, macro-molecular complex of iron (III) hydroxide and isomaltose. It is used in the treatment of iron-deficiency anaemia.
Storage
Intramuscular:
Store below 25°C. Do not freeze.
Intravenous:
Store below 25°C. Do not freeze.
Oral:
Store below 25°C.
Disclaimer: This information is independently developed by MIMS based on Iron polymaltose from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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