Iron sucrose


Concise Prescribing Info
Indications/Uses
Iron-deficiency anaemia.
Dosage/Direction for Use
Adult : IV In cases wherein oral Fe therapy is ineffective or impractical: Total cumulative dose is calculated individually based on body wt and Hb level. Usual dose: 5-10 mL (100-200 mg elemental Fe) 1-3 times wkly. Haemodialysis-dependent patient: 100 mg during each consecutive dialysis session. Usual cumulative dose: 1,000 mg. Peritoneal dialysis-dependent patient: 300 mg for the 1st 2 doses, 14 days apart, followed by 400 mg 14 days later. Nondialysis-dependent patient: 200 mg, given in 5 different occasions over a 14-day period. Treatment may be repeated if necessary.
Dosage Details
Intravenous
Iron-deficiency anaemia in chronic renal failure
Adult: Haemodialysis-dependent patient: 100 mg via slow inj over 2-5 min or via infusion over at least 15 min, during each consecutive dialysis session. Usual cumulative dose: 1,000 mg. Peritoneal dialysis-dependent patient: 300 mg via infusion over 1.5 hr for the 1st 2 doses, 14 days apart, followed by 400 mg via infusion over 2.5 hr 14 days later. Nondialysis-dependent patient: 200 mg via slow inj over 2-5 min or via infusion over 15 min, given in 5 different occasions over a 14-day period. Treatment may be repeated if necessary.
Child:  ≥2 yr As maintenance therapy: Haemodialysis-dependent patient: 0.5 mg/kg (Max: 100 mg) every 2 wk for 12 wk. Nondialysis-dependent or peritoneal dialysis-dependent patients who are receiving erythropoietin therapy: 0.5 mg/kg (Max: 100 mg) every 4 wk for 12 wk. Doses may be given via slow inj over 5 min or via infusion over 5-60 min. Treatment may be repeated if necessary.

Intravenous
Iron-deficiency anaemia
Adult: In cases wherein oral Fe therapy is ineffective or impractical: Total cumulative dose is calculated individually based on body wt and Hb level. Usual dose: 5-10 mL (100-200 mg elemental Fe) 1-3 times wkly via slow inj at a rate of 20 mg/min or via infusion at a rate of ≤100 mg/15 min.
Reconstitution
Soln for infusion: Adult: Dilute in a max of 100 mL (doses ≤200 mg) or 250 mL (doses >200 mg) of NaCl 0.9%. Childn: Dilute in 25 mL of NaCl 0.9%.
Contraindications
Hypersensitivity to Fe sucrose or other parenteral Fe products. Anaemia not caused by Fe deficiency, evidence of Fe overload or hereditary disturbances in utilisation of Fe. 1st trimester of pregnancy.
Special Precautions
Patient w/ immune or inflammatory conditions, acute or chronic infections, history of asthma, eczema, or other atopic allergies. Hepatic impairment. Pregnancy (2nd and 3rd trimester) and lactation.
Adverse Reactions
Significant: Hypotension.
Nervous: Headache, dizziness, loss of consciousness, collapse, seizures.
CV: Chest pain, peripheral oedema.
GI: Diarrhoea, nausea, vomiting.
Resp: Dyspnoea.
Musculoskeletal: Pain in extremity, arthralgia, back pain, muscle cramps.
Dermatologic: Pruritus.
Others: Inj site reactions.
Potentially Fatal: Anaphylactic reactions.
IV/Parenteral: B
Patient Counseling Information
This drug may cause dizziness, confusion, or lightheadedness, if affected, do not drive or operate machinery.
MonitoringParameters
Monitor Hb, haematocrit, serum ferritin, and transferrin saturation periodically. Monitor closely for signs and symptoms of hypersensitivity during and after admin.
Overdosage
Symptoms: Fe overload, manifested as haemosiderosis. Management: Supportive treatment. Fe chelating agent may be given as required.
Drug Interactions
May reduce the absorption of oral Fe preparations.
Action
Description: Iron sucrose is an aqueous complex of polynuclear Fe(III)-hydroxide and sucrose which is  broken down into iron and sucrose by the reticuloendothelial system. This results in increased serum iron concentrations and is incorporated into haemoglobin.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 10 min.
Distribution: Distributed mainly in the blood and to some extent in extravascular fluid.
Metabolism: Dissociated into Fe and sucrose by macrophages of the reticuloendothelial system in the liver, spleen, and bone marrow.
Excretion: Via urine (approx 5%). Terminal elimination half-life: Approx 6 hr.
Chemical Structure

Click on icon to see table/diagram/image
Storage
Store between 20-25°C. Do not freeze.
Disclaimer: This information is independently developed by MIMS based on Iron sucrose from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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