Isoket IV

Isoket IV

isosorbide dinitrate

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Isosorbide dinitrate
Indications/Uses
Unresponsive left ventricular failure secondary to acute MI or of various aetiology. Severe or unstable angina pectoris.
Dosage/Direction for Use
2-12 mg IV every hr, may be increased up to 20 mg every hr.
Contraindications
Hypersensitivity to nitrates or nitrites. Low filling pressure, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, cardiogenic shock, circulatory collapse, aortic &/or mitral valve stenosis, severe hypotension (systolic BP <90 mmHg), head trauma & cerebral haemorrhage, increased intracranial pressure-associated diseases, marked anaemia, hypovolaemia, closed-angle glaucoma. Concomitant use w/ phosphodiesterase-5 inhibitors eg, sildenafil, tadalafil, vardenafil.
Special Precautions
Patients w/ hypothyroidism, hypothermia, malnutrition, orthostatic syndrome. Development of tolerance; hypoxia particularly in patients w/ CAD leading to myocardial hypoxia. Monitor BP & pulse rate. Patients on controlled Na diet. May affect ability to drive or operate machinery. Renal & hepatic impairment. Pregnancy & lactation. Childn.
Drug Interactions
Potentiated hypotensive effects w/ phosphodiesterase-5 inhibitors eg, sildenafil; BP-lowering drugs (eg, β-blockers, Ca antagonists, vasodilators) &/or alcohol; neuroleptics & TCAs. Increased blood level & antihypertensive effect of dihydroergotamine.
MIMS Class
Anti-Anginal Drugs
ATC Classification
C01DA08 - isosorbide dinitrate ; Belongs to the class of organic nitrate vasodilators. Used in the treatment of cardiac disease.
Presentation/Packing
Form
Isoket IV soln for infusion 10 mg/10 mL
Packing/Price
10 × 1's
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