Ixime Side Effects





Full Prescribing Info
Side Effects
Cefixime is generally well tolerated.
The majority of adverse reactions observed in clinical trials were mild and self-limiting in nature.
Gastrointestinal Disturbances: The most frequent side effects seen with Cefixime are diarrhoea and stool changes with diarrhoea being been more commonly associated with higher doses.
Some cases of moderate to severe diarrhoea have been reported; this has occasionally warranted cessation of therapy. Ixime should be discontinued if marked diarrhoea occurs. Other gastrointestinal side effects seen less frequently are nausea, abdominal pain, dyspepsia, vomiting and flatulence.
Pseudomembranous colitis has been reported.
Central Nervous System: Headache and dizziness.
Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced.
If seizures associated with drug therapy occur, the drug should be discontinued.
Anticonvulsant therapy can be given if clinically indicated.
Hypersensitivity Reactions: Allergies in the form of rash, pruritus, urticaria, drug fever and arthralgia have been observed.
These reactions usually subsided upon discontinuation of therapy.
Rarely Erythema multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis have been reported.
Haematological and Clinical Chemistry: Thrombocytopenia, leukopenia and eosinophilia have been reported though these reactions were infrequent and reversible.
Mild transient changes in liver and renal function tests too have been observed.
Hepatic Disorders: Transient rises in liver transaminases, alkaline phosphatase and jaundice can also occur.
Miscellaneous: Other possible reactions include genital pruritus and vaginitis.
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