Janumet

Janumet

metformin + sitagliptin

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 50/500 mg tab Sitagliptin phosphate 50 mg, metformin HCl 500 mg. Per 50/850 mg tab Sitagliptin phosphate 50 mg, metformin HCl 850 mg. Per 50/1,000 mg tab Sitagliptin phosphate 50 mg, metformin HCl 1,000 mg
Indications/Uses
Initial therapy in type 2 DM when diet & exercise do not provide adequate glycemic control. Adjunct to diet & exercise to improve glycemic control in type 2 DM inadequately controlled on metformin or sitagliptin alone, or combination sitagliptin & metformin, or triple combination sitagliptin, metformin or sulfonylurea, or max tolerated dose of metformin & PPARγ agonist, or insulin & metformin alone.
Dosage/Direction for Use
Individualized dosage. Initially 50 mg/500 mg bd. Max daily dose: Sitagliptin 100 mg/metformin 2 g.
Administration
Should be taken with food.
Contraindications
Acute or chronic metabolic acidosis including diabetic ketoacidosis, intravascular administration of iodinated contrast materials. Renal disease or dysfunction. Pregnancy & lactation.
Special Precautions
Not for use in type 1 DM or treatment of ketoacidosis. Sulfonylurea- or insulin-induced hypoglycemia, risk of lactic acidosis, hypoxic states, surgery, alcohol intoxication, decreased vit B12 absorption, loss of glycemic control. Renal & hepatic impairment. Childn <18 yr. Elderly.
Adverse Reactions
Diarrhea, nausea, dyspepsia, flatulence, vomiting, headache, hypoglycaemia; abdominal pain, loss of appetite, metallic taste, upper resp tract infection, hypersensitivity reactions.
Drug Interactions
Metformin: Furosemide, nifedipine, cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin). Thiazides & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca antagonists, INH.
MIMS Class
ATC Classification
A10BD07 - metformin and sitagliptin ; Belongs to the class of combinations of oral blood glucose lowering drugs. Used in the treatment of diabetes.
Presentation/Packing
Form
Janumet 50/850 mg FC tab
Packing/Price
56's
Form
Janumet 50/500 mg FC tab
Packing/Price
56's
Form
Janumet 50/1,000 mg FC tab
Packing/Price
56's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in