Janumet Contraindications

metformin + sitagliptin


Merck Sharp & Dohme


Zuellig Pharma
Full Prescribing Info
Known hypersensitivity to sitagliptin phosphate, metformin hydrochloride or to any of the excipients of Janumet (see Precautions).
Renal disease or renal dysfunction eg, as suggested by serum creatinine levels ≥1.5 mg/dL (males), ≥1.4 mg/dL (females) or abnormal creatinine clearance which may also result from conditions eg, cardiovascular collapse (shock), acute myocardial infarction and septicemia.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma.
Janumet should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials because the use of such products may result in acute alteration of renal function (see Precautions).
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