Keppra

Keppra

levetiracetam

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Levetiracetam
Indications/Uses
Monotherapy in treatment of partial onset seizures w/ or w/o secondary generalisation in patients from 16 yr w/ newly diagnosed epilepsy. Adjunctive treatment of partial onset seizures w/ or w/o secondary generalisation in adults & childn from 4 yr w/ epilepsy; myoclonic seizures in adults & adolescents from 12 yr w/ juvenile myoclonic epilepsy; primary generalised tonic-clonic seizures in adults & adolescents from 12 yr w/ idiopathic generalised epilepsy.
Dosage/Direction for Use
Monotherapy Adult & adolescent from 16 yr 250 mg bd, may be increased to 500 mg bd after 2 wk. Max: 1,500 mg bd. Add-on therapy Adult ≥18 yr & adolescent 12-17 yr, ≥50 kg Initially 500 mg bd, may be increased up to 1,500 mg bd. Dose changes can be made in 500 mg bd increases or decreases every 2-4 wk. Childn 4-11 yr & adolescent 12-17 yr, <50 kg Initially 10 mg/kg bd, may be increased up to 30 mg/kg bd. Dose changes should not exceed increases or decreases of 10 mg/kg bd every 2 wk. Childn ≥50 kg Adult dose.
Administration
May be taken with or without food: Oral soln: May be diluted in a glass of water.
Contraindications
Hypersensitivity to levetiracetam or other pyrrolidone derivatives.
Special Precautions
Monitor for signs of depression &/or suicidal ideation & behaviours. Perform complete blood cell count. Avoid abrupt w/drawal. May affect ability to drive or operate machinery. Acute kidney injury. Renal & severe hepatic impairment. Women of childbearing potential. Pregnancy. Not recommended during lactation. Elderly. Tab: Not to be used in childn <6 yr & <25 kg. Oral soln: Allergic reaction due to methyl & propyl parahydroxybenzoate. Headache & GI disturbances due to glycerol. Fructose intolerance.
Adverse Reactions
Nasopharyngitis; somnolence, headache. Anorexia; depression, hostility/aggression, anxiety, insomnia, nervousness/irritability; convulsion, balance disorder, dizziness, lethargy, tremor; vertigo; cough; abdominal pain, diarrhoea, dyspepsia, nausea, vomiting; rash; asthenia/fatigue.
Drug Interactions
Decreased methotrexate clearance. Decreased efficacy w/ macrogol. Reduced absorption by food.
MIMS Class
Anticonvulsants
ATC Classification
N03AX14 - levetiracetam ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Keppra FC tab 1 g
Packing/Price
100's
Form
Keppra FC tab 250 mg
Packing/Price
100's
Form
Keppra FC tab 500 mg
Packing/Price
100's
Form
Keppra oral soln 100 mg/mL
Packing/Price
(grape flavour) 300 mL x 1's
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