Initially 25 mg bd, increased to 25-50 mg bd or tds on 2nd or 3rd day, to target range: 300-400 mg daily by 4th day bd or tds. Range: 150-750 mg daily. Acute manic episodes associated w/ bipolar disorder
Total daily dose for 1st 4 days of therapy: 100 mg (day 1), 200 mg (day 2), 300 mg (day 3) & 400 mg (day 4), adjusted up to 800 mg daily by day 6 in no >200 mg daily increments. Usual effective dose range: 400-800 mg daily. Elderly, renal & hepatic impairment
Initially 25 mg daily, increased in increments of 25-50 mg daily.