Klacid Tablet: Clarithromycin recommended dosage in adults is one 500-mg tab every 12 hrs.
Administration must be continued, according to severity of infection, up to 6-14 days.
In patients with renal impairment with creatinine clearance <30 mL/min, the dosage should be reduced by ½. Dosage should not be continued beyond 14 days in these patients.
Klacid Granules For Oral Suspension 250 mg/5 mL: Children >8-12 years; 30-40 kg: 5 mL twice daily, >5-8 years; 20-29 kg: 3.75 mL twice daily.
Klacid Granules For Oral Suspension 125 mg/5 mL: Children 2-5 years; 12-19 kg: 5 mL twice daily, 6 months-2 years; 8-11 kg: 2.5 mL twice daily.
The recommended daily dosage of clarithromycin paediatric suspension (125 mg/5 mL) in children is given in the following table and is based on a 7.5 mg/kg twice daily regimen. Doses up to 500 mg twice daily have been used in the treatment of serious infections. (See table.)
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Patients with Renal Impairment: In children with creatinine clearance <30 mL/min, the dosage of clarithromycin should be reduced by ½ ie, up to 250 mg once daily, or 250 mg twice daily in more severe infections. Dosage should not be continued beyond 14 days in these patients.
The usual duration of treatment is 5-10 days, depending on the pathogen involved and the severity of the condition. Treatment for streptococcal pharyngitis should be at least 10 days.
Suspension Preparation: To prepare Klacid suspension, add water to the granules contained in the bottle until the line impressed on it. Shake well. Add more water up to the line. The prepared suspension can be taken with or without meals, and can be taken with milk.
Klacid MR: 500 mg once daily with food.
Severe Infections: 1000 mg (2 x 500 mg) once daily with food.
Duration of Treatment: 6-14 days.