Klacid/Klacid MR

Klacid/Klacid MR Drug Interactions





Zuellig Pharma
Full Prescribing Info
Drug Interactions
Results of clinical studies indicate that there was a modest but statistically significant increase (p=0.05) of circulating theophylline or carbamazepine levels when either of these drugs are administered concomitantly with clarithromycin. As with other macrolide antibiotics, the use of clarithromycin in patients concurrently taking drugs metabolized by the cytochrome P-450 system (eg, digoxin, warfarin) may be associated with elevations in serum levels of these other drugs.
Macrolides have been reported to alter the metabolism of terfenadine resulting in increased levels of terfenadine which has occasionally been associated with cardiac arrhythmias. In 1 study in 14 healthy volunteers, the concomitant administration of clarithromycin and terfenadine resulted in 2- to 3-fold increases in the serum level of the acid metabolite of terfenadine and in prolongation of the QT-interval which did not lead to any clinically detectable effect.
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