Adult CINV & prevention of RINV 1-3 mg slow IV inj over 30 sec or IV infusion over 5 min prior chemo- &/or RT. CINV Max dose: 9 mg over 24 hr. PONV prevention 1 mg slow IV inj over 30 sec prior to anesth induction. PONV treatment 1 mg slow IV inj over 30 sec. Max dose: 3 mg daily. Ped CINV 10-40 mcg/kg IV infusion over 5 min prior to chemotherapy, may administer additional dose w/in 24 hr at least 10 min after initial dose.
Signs of subacute intestinal obstruction, cardiac co-morbidities. Patients on cardiotoxic chemotherapy &/or w/ concomitant electrolyte abnormalities. Concomitant use w/ other serotonergic drugs. May affect ability to drive. Pregnancy & lactation.