Lamoga-50/Lamoga-100

Lamoga-50/Lamoga-100

lamotrigine

Manufacturer:

Unison

Distributor:

Medispec
Concise Prescribing Info
Contents
Lamotrigine
Indications/Uses
Adjunctive or monotherapy in treatment of epilepsy for partial & generalized seizures including tonic-clonic seizures & seizures associated w/ Lennox-Gastaut syndrome. Prevention of mood episodes in patients w/ bipolar disorder predominantly by preventing depressive episodes.
Dosage/Direction for Use
Adult >16 yr Epilepsy monotherapy Initially 25 mg once daily for 2 wk, followed by 50 mg once daily for 2 wk. May be increased by 50-100 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses. Adult >12 yr Add-on therapy w/ valproate Initially 25 mg every alternate day for 2 wk, followed by 25 mg once daily for 2 wk. May be increased by 25-50 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses. Add-on therapy w/ antiepileptics or other medications inducing lamotrigine glucuronidation Initially 50 mg once daily for 2 wk, followed by 100 mg daily in 2 divided doses for 2 wk. May be increased by 100 mg every 1-2 wk. Maintenance: 200-400 mg daily in 2 divided doses. Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation Initially 25 mg once daily for 2 wk, followed by 50 mg once daily for 2 wk. May be increased by 50-100 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses. Childn 2-12 yr Add-on therapy w/ valproate Initially 0.15 mg/kg once daily for 2 wk, followed by 0.3 mg/kg once daily for 2 wk. May be increased by 0.3 mg/kg every 1-2 wk. Maintenance: 1-5 mg/kg once daily or in 2 divided doses. Max: 200 mg daily. Add-on therapy w/ antiepileptics or other medications inducing lamotrigine glucuronidation Initially 0.6 mg/kg daily in 2 divided doses for 2 wk, followed by 1.2 mg/kg daily in 2 divided doses for 2 wk. May be increased by 1.2 mg/kg every 1-2 wk. Maintenance: 5-15 mg/kg daily in 2 divided doses. Max: 400 mg daily. Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation Initially 0.3 mg/kg once daily or in 2 divided doses for 2 wk, followed by 0.6 mg/kg once daily or in 2 divided doses for 2 wk. May be increased by 0.6 mg/kg every 1-2 wk. Maintenance: 1-10 mg/kg once daily or in 2 divided doses. Max: 200 mg daily. Adult ≥18 yr Bipolar disorder adjunct therapy w/ valproate Initially 25 mg every alternate day for 2 wk, followed by 25 mg once daily for 2 wk. May be increased to 50 mg once daily or in 2 divided doses for 1 wk. Usual target dose: 100 mg once daily or in 2 divided doses, may be increased to max: 200 mg daily. Adjunct therapy w/ phenytoin, carbamazepine, phenobarb, primidone & other drugs inducing lamotrigine glucuronidation Initially 50 mg once daily for 2 wk, followed by 100 mg daily in 2 divided doses for 2 wk. May be increased to 200 mg daily in 2 divided doses for 1 wk, then further increased to 300 mg daily for 1 wk. Usual target dose: 400 mg daily in 2 divided doses for 1 wk. Monotherapy or adjunct therapy w/ drugs that do not significantly induce or inhibit lamotrigine glucuronidation Initially 25 mg once daily for 2 wk, followed by 50 mg once daily or in 2 divided doses for 2 wk. May be increased to 100 mg once daily or in 2 divided doses for 1 wk. Usual target dose: 200 mg once daily or in 2 divided doses.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Special Precautions
History of allergy or rash to other antiepileptic drugs. Not to be restarted in patients who have discontinued due to rash or aseptic meningitis associated w/ prior treatment. Not recommended for initial monotherapy treatment in newly diagnosed ped patients. Haemophagocytic lymphohistiocytosis; patients w/ Brugada syndrome. Monitor for clinical worsening, suicidal ideation/behaviour, thoughts. Avoid abrupt w/drawal. Interference w/ folate metabolism during long-term use. Not to be administered in patients currently being treated w/ other lamotrigine-containing prep. Concomitant use w/ hormonal contraceptives. Renal failure. Hepatic impairment. Pregnancy & lactation. Not to be used for bipolar disorder in childn & adolescents <18 yr. Major depressive & other psychiatric disorders in childn & adolescents <18 yr. Childn <2 yr w/ epilepsy.
Adverse Reactions
Skin rash; headache. Aggression, irritability; somnolence, insomnia, dizziness, tremor; nausea, vomiting, diarrhea; agitation; arthralgia; pain, back pain.
Drug Interactions
Inhibited glucuronidation by valproate. Induced glucuronidation by phenytoin, carbamazepine, phenobarb, primidone, rifampicin, lopinavir/ritonavir/atazanavir, ethinylestradiol/levonorgestrel combination.
MIMS Class
Anticonvulsants
ATC Classification
N03AX09 - lamotrigine ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Lamoga-100 FC tab 100 mg
Packing/Price
3 × 10's
Form
Lamoga-50 FC tab 50 mg
Packing/Price
3 × 10's
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