Lanvis

Lanvis

tioguanine

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Thioguanine
Indications/Uses
Acute myelogenous leukaemia, acute lymphoblastic & chronic granulocytic leukaemia.
Dosage/Direction for Use
Induction therapy 100-200 mg/m2 daily on single or bd dosing for 5-20 days. Maintenance Intermittent or continuous daily dose of 60-200 mg/m2.
Administration
Should be taken on an empty stomach.
Contraindications
1st trimester of pregnancy.
Special Precautions
Monitor full blood count frequently during remission induction. Inherited deficiency of thiopurine methyltransferase enzyme, Lesch-Nyhan syndrome. Renal or hepatic impairment. Ensure adequate contraceptive precautions. Pregnancy & lactation.
Adverse Reactions
Bone marrow suppression, GI intolerance, stomatitis, intestinal necrosis & perforation, liver function abnormalities, jaundice, veno-occlusive liver disease.
Drug Interactions
Busulphan, aminosalicylate derivatives eg, sulfasalazine, olsalazine or meslazine.
ATC Classification
L01BB03 - tioguanine ; Belongs to the class of antimetabolites, purine analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Lanvis tab 40 mg
Packing/Price
25's
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