Letram

Letram

levetiracetam

Manufacturer:

Hetero Labs

Distributor:

Unimed
Concise Prescribing Info
Contents
Levetiracetam
Indications/Uses
Monotherapy for partial onset seizures w/ or w/o secondary generalisation in patients from 16 yr w/ newly diagnosed epilepsy. Adjunctive therapy for partial onset seizures w/ or w/o secondary generalisation in adults & childn from 4 yr w/ epilepsy; myoclonic seizures in adults & adolescents from 12 yr w/ juvenile myoclonic epilepsy; primary generalized tonic-clonic seizures in adults & adolescents from 12 yr w/ idiopathic generalised epilepsy.
Dosage/Direction for Use
Monotherapy Adult & adolescent from 16 yr Initially 250 mg bd, may be increased to 500 mg bd after 2 wk. May be further increased by 250 mg bd every 2 wk. Max: 1,500 mg bd. Add-on therapy Adult 18 yr & adolescent 12-17 yr, ≥50 kg Initially 500 mg bd, may be increased up to 1,500 mg bd. Dose changes can be made in 500 mg bd increases or decreases every 2-4 wk. Childn 4-11 yr & adolescent 12-17 yr, <50 kg Initially 10 mg/kg bd, may be increased up to 30 mg/kg bd. Dose changes not to exceed 10 mg/kg bd increases or decreases every 2 wk. Childn ≥50 kg Adult dose.
Administration
May be taken with or without food: Oral soln may be diluted in a glass of water.
Contraindications
Hypersensitivity to levetiracetam or other pyrrolidone derivatives.
Special Precautions
Increased risk of suicidal thoughts or behaviours. Avoid abrupt w/drawal. May affect ability to drive & use machines. Acute renal injury. Renal or severe hepatic impairment. Not to be used during pregnancy. Not recommended during lactation. Monotherapy treatment in childn & adolescents <16 yr. Tab: Not to be used in childn <6 yr & <25 kg.
Adverse Reactions
Somnolence, headache; asthenia, fatigue; nasopharyngitis. Abdominal pain, diarrhoea, dyspepsia, nausea, vomiting; convulsion, dizziness, tremor, balance disorder; aggression, depression, hostility, insomnia, irritability, nervousness; anorexia; vertigo; cough; rash. Tab: Thrombocytopenia; memory impairment; diplopia, blurred vision; infection; muscular weakness, myalgia; acute kidney injury. Oral soln: Anxiety; lethargy.
Drug Interactions
MIMS Class
Anticonvulsants
ATC Classification
N03AX14 - levetiracetam ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Letram FC tab 250 mg
Packing/Price
10 × 10's
Form
Letram FC tab 500 mg
Packing/Price
10 × 10's
Form
Letram oral soln 100 mg/mL
Packing/Price
(grape flavour) 150 mL x 1's; (grape flavour) 300 mL x 1's
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