Generic Medicine Info
Indications and Dosage
Ocular hypertension, Open-angle glaucoma
Adult: As 0.25% drops: Instill 1-2 drops in the affected eye(s) bid. As 0.5% drops: Instill 1-2 drops in the affected eye(s) once daily, may increase to 1 drop bid.
Sick sinus syndrome, sinus bradycardia, 2nd and 3rd degree AV block, asthma or history of asthma, severe COPD, cardiogenic shock, overt cardiac failure.
Special Precautions
Patients w/ diminished pulmonary function, nonallergic bronchospasm, inadequate cardiac function, DM, myasthenia gravis. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Avoid abrupt withdrawal as it may precipitate thyroid storm. Pregnancy and lactation.
Adverse Reactions
Ocular stinging, burning, blepharoconjunctivitis, blepharitis, decreased visual acuity, band keratopathy, erythema, iridocyclitis, conjunctivitis and itching sensation; bradycardia, CVA, syncope, arrhythmia, heart block, hypotension, cerebral ischaemia, bronchospasm. Rarely, reduced corneal sensitivity and tearing.
Patient Counseling Information
Do not drive or operate machinery until vision is clear.
Drug Interactions
Additive hypotensive effect w/ catecholamine-depleting drug (e.g. reserpine), Ca channel blockers, β-adrenergic blockers, digitalis glycosides, antiarrhythmics, guanethidine, parasympathomimetics. Mydriasis may occur when used w/ epinephrine.
Description: Levobunolol is a nonselective β-adrenergic blocking agent. It causes the reduction of intraocular pressure by decreasing the production of aqueous humour.
Onset: W/in 1 hr.
Duration: Up to 24 hr.
Absorption: Some absorbed systematically.
Store between 15-30°C. Protect from light.
MIMS Class
Antiglaucoma Preparations
Anon. Levobunolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com.

Buckingham R (ed). Levobunolol Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com.

McEvoy GK, Snow EK, Miller J et al (eds). Levobunolol Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com.

Disclaimer: This information is independently developed by MIMS based on Levobunolol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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