Lidocaine + Epinephrine + Tetracaine

Generic Medicine Info
Indications and Dosage
Analgesia to nonintact skin
Adult: As liquid or gel containing lidocaine 4%, epinephrine 1:2 000 and tetracaine 0.5%: Apply 1-3 ml directly onto wound for 15-30 minutes.
Not to be used on procedures involving digits, ears, nose, penis or scrotum due to risk of ischaemic tissue necrosis.
Special Precautions
Caution when used on contaminated wounds, complex wounds or wounds >6 cm. Does not work on intact skin. Hepatic impairment. Risk of additive toxicity when used in patients who are receiving class I antiarrhythmics or local anaesthetics. Patients with asthma, bronchitis, emphysema, inflamed/damaged mucosa, heart disease, children <12 mth. Caution when used in smokers or patients with haemoglobin or enzyme abnormalities. Acutely-ill patients, elderly, debilitated patients. Pregnancy.
Adverse Reactions
Dizziness, fever, headache, nausea, vomiting, pruritus, pain, pallor. Acne, allergic reaction, anaphylactoid reaction, angioedema, blister, bronchospasm, bruising, confusion, dehydration, diaphoresis, hyperventilation, hypotension, infection, nervousness, paresthesia, petechiae, pharyngitis, somnolence, stupor, syncope, urticaria, vesiculobullous rash.
Drug Interactions
Additive and potentially synergistic effects when used with class I antiarrhythmics. Increased risk of methaemoglobin when used with methaemoglobin-inducing medications.
Mechanism of Action: Lidocaine and tetracaine are local anaesthetic agents that work by stabilising neuronal membranes and inhibiting sodium ion fluxes required for initiation and conduction of impulses. Epinephrine is a potent agonist on both α and β-adrenoceptors. It is usually used with local anaesthetics to slow down diffusion and prolong drug action.
Onset: 20-30 minutes.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01BA53 - tetracaine, combinations ; Belongs to the class of esters of aminobenzoic acid. Used as local anesthetics.
Disclaimer: This information is independently developed by MIMS based on Lidocaine + Epinephrine + Tetracaine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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