Lindane


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Scabies As 1% preparation: Apply on all skin areas from the neck to toes. Wash off after 8-12 hr. Pediculosis As 1% shampoo: Apply 30-60 mL to dry hair. Max: 60 mL. Massage into hair for 4 mins, then rinse thoroughly.
Dosage Details
Topical/Cutaneous
Scabies
Adult: Apply a thin layer of 1% topical preparation onto all skin areas from the neck to toes. Completely wash off from the body with warm water after 8-12 hr.

Topical/Cutaneous
Pediculosis
Adult: Apply 30-60 ml of 1% shampoo to dry hair. Amount depends on the length of the hair; most patients will require 30 ml (max 60 ml). Massage into hair for 4 min then add small quantities of water to form a good lather. Immediately rinse thoroughly until all the lather is gone. Dry the hair and comb with a fine tooth comb.
Contraindications
Hypersensitivity. Uncontrolled seizures; broken skin; premature infant. Lactation.
Special Precautions
Infants, small children, patients <50 kg, history of seizures or conditions which may increase risk of seizures. Hepatic impairment. Avoid contact with face, eyes, mucous membranes and urethral meatus. Pregnancy.
Adverse Reactions
Cardiac arrhythmia, ataxia, dizziness, headache, restlessness, seizure, pain, alopecia, contact dermatitis, eczematous eruptions, pruritus, urticaria, nausea, vomiting, aplastic anaemia, hepatitis, burning and stinging, paraesthesia, haematuria, pulmonary oedema.
Potentially Fatal: Severe neurologic toxicities.
Overdosage
Symptoms: Vomiting, restlessness, ataxia, seizures, arrhythmias, pulmonary oedema, haematuria, hepatitis. Occasionally, severe CNS, hepatic, renal toxicity (excessive use for prolonged periods). Management: Gastric lavage (if ingested) and general supportive measures.
Drug Interactions
Enhanced absorption and increased risk of toxicity with oils and oil-based preparations.
Potentially Fatal: Increased toxicity with drugs that lower seizure threshold e.g. antidepressants, antipsychotics, ciclosporin, isoniazid.
Action
Description: Lindane stimulates the nervous system of parasites by direct absorption through their exoskeletons causing seizures and death.
Pharmacokinetics:
Absorption: ≤13% (systemic absorption after topical application); peak plasma concentrations after 6 hr in children.
Distribution: Stored in body fat, accumulates in brain; skin and adipose tissue.
Metabolism: Hepatic.
Excretion: Via urine and faeces; 17-22 hr (elimination half-life in children).
Storage
Store at controlled room temperature.
Disclaimer: This information is independently developed by MIMS based on Lindane from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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