Taisho Pharmaceutical


Zuellig Pharma
Concise Prescribing Info
Relief of pain & inflammation associated w/ OA.
Dosage/Direction for Use
Adult Apply to affected area once daily. Max: Not >2 patches at once or daily.
Hypersensitivity to esflurbiprofen or flurbiprofen. Peptic ulcer; severe blood abnormality, cardiac dysfunction & HTN. Current or previous aspirin-induced asthma. Concomitant use w/ enoxacin hydrate, lomefloxacin, norfloxacin or prulifloxacin. Severe hepatic & renal disorder. Late pregnancy.
Special Precautions
Hypersensitivity reactions. Not to be applied to skin wounds, open injuries, mucous membrane, area of eczema or rash. History of peptic ulcer & other risk factors associated w/ PUD eg, alcoholism, smoking, corticosteroid therapy. Blood abnormality; bleeding tendency; abnormal cardiac function; HTN; bronchial asthma; ulcerative colitis; Crohn's disease. Perform periodic laboratory tests eg, urine analysis, blood & liver function test. Not be used concomitantly w/ enoxacin hydrate, lomefloxacin, norfloxacin or prulifloxacin. Avoid use w/ quinolones. Long-term use. Hepatic or renal disorder. Not to be used during late pregnancy. Avoid use during lactation. Low-birth wt babies, neonates, nursing infants, infants & childn. Elderly w/ hyperthermia or patients w/ debilitating diseases.
Adverse Reactions
Dermatitis, erythema, pruritus, eczema, rash; increased blood urea.
Drug Interactions
Induced convulsions w/ enoxacin hydrate, lomefloxacin, norfloxacin, prulifloxacin, ofloxacin. Increased effect of coumarin anticoagulants eg, warfarin. Increased blood levels of methotrexate, lithium. Decreased effects of thiazide & loop diuretics. Increased GI reactions w/ corticosteroids. Increased blood levels w/ CYP2C9 inhibitors.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
M02AA29 - esflurbiprofen ; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains.
Locoa transdermal patch 40 mg
(10 x 14 cm) 10 × 7's
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