Lycan Dosage/Direction for Use

Lidocaine Injection is for one dose in one patient only, discard any remaining contents.
As a local anaesthetic for infiltration and nerve block: The dosage varies and depends upon the area to be anaesthetised, vascularity of the tissues, number of neuronal segments to be blocked, individual tolerance and the technique of anaesthesia. The lowest dose needed to provide effective anaesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.
It is recommended that the dose of lidocaine at any one time should not exceed 3mg/kg. However, the dose administered must be tailored to the individual patient and procedure, and the maximum doses here quoted should be used as a guide only.
Adult: The normal recommended dosage of lidocaine for various anaesthesic procedures in average, healthy 70kg adult patients are as follows: (See table.)

Click on icon to see table/diagram/image

The doses suggested previously are only a guide. Toxic levels vary widely between patients so doses should be individualised and blood levels should be monitored.
Epidural injections should be administered slowly with frequent aspirations. Subarachnoid and intravascular injections are two of the most serious complications of this technique. If blood or spinal fluid become manifest during aspiration, the needle must be withdrawn and relocated.
The technique of epidural anaesthesia should only be attempted by physicians skilled in this area and readiness for emergencies must be ensured. During spinal anaesthesia the positioning of the patient is very important and the patient's pulse and blood pressure should be monitored. During thoracic, lumbar and caudal epidural anaesthesia, a marked fall in blood pressure and/or intercostal paralysis may be seen, possibly due to the use of excessive doses, improper positioning of the patient or accidental disposition of the anaesthetic within the subarachnoid space. Hypotension and bradycardia may occur as a result of sympathetic blockade.
For continuous epidural or caudal anaesthesia and paracervical block for obstetric analgesia the maximum dose should not be repeated at intervals of less than 1.5 hours.
Adults: The dose should not exceed 200mg. For spinal anaesthesia, the dose should not exceed 100mg.
Children: For children, a reduced dosage based on body weight or surface area should be used. The dosage should be calculated for each patient individually and modified in accordance with the physician's experience and knowledge of the patient. Early signs of local anaesthetic toxicity may be difficult to detect in cases where the block is given during general anaesthesia.
The dose should not exceed 3mg/kg.
For intravenous use in cardiac arrhythmias: Patients with congestive heart failure or cardiogenic shock may require smaller bolus doses.
Adults: The usual dose is lignocaine 50 to 100mg administered intravenously under ECG monitoring. The dose may be injected at a rate of approximately 25 to 50mg (1.25 to 2.5ml of the 2% solution) per minute. A sufficient period of time should be allowed to enable a slow circulation to carry the drug to the site of action. If the initial dose of 50 to 100mg does not produce the desired response, a second dose may be given after five minutes. No more than 200 to 300mg of lignocaine should be administered during a one hour period.
Following a single injection in those patients in whom arrhythmia tends to recur and who are incapable of receiving oral antiarrhythmic therapy, intravenous infusions of lignocaine may be administered at a rate of 1 to 4mg/minute (20 to 50 mcg/kg/minute). Intravenous infusions must be given under ECG monitoring to avoid potential overdosage and toxicity. The infusion should be terminated as soon as the patient's cardiac rhythm appears to be stable or at the earliest signs of toxicity. It should rarely be necessary to continue the infusion beyond 24 hours. As soon as possible, patients should be changed to an oral antiarrhythmic agent for maintenance therapy.
Paediatrics: For children, a reduced dose based on body weight or surface area should be used. Experience with lignocaine is limited. A suggested paediatric dose is a loading dose of 0.5 to 1mg/kg repeated if necessary up to 3-5mg/kg, followed by continuous infusions of 10 to 50 micrograms/kg/min.
Use in elderly: A reduction in dosage may be necessary for elderly patients especially those with compromised cardiovascular and/or hepatic function.
Impaired hepatic function: Although lidocaine is metabolised by the liver, dosage reduction for local anaesthesia is probably not warranted. However, caution should be exercised with repeated doses.
Impaired renal function: Impairment of renal function is unlikely to affect lidocaine clearance in short term (24 hours). However, toxicity due to accumulation may develop with prolonged or repeated administration.
Route of Administration: For parenteral use (epidural/caudal/IV use).