Topical/Cutaneous Adjunct in the treatment of infection in second degree burn, Adjunct in the treatment of infection in third degree burn
Adult: As 8.5% cream: Apply a layer approx 1/16 inch 1-2 times daily. Continue until wound healing progresses or burn site ready for grafting. As 5 % soln: Wet an 8-ply burn dressing w/ soln and cover graft area. Keep dressing wet by using syringe or irrigation tubing (4 hrly or as necessary) or by moistening the dressing (6-8 hrly or as necessary). Continue until autograft vascularisation occurs and wound healing progresses. Wound dressing may be left in place for up to 5 days. Child: As 8.5% cream: Same as adult dose. As 5% soln: ≥3mth Same as adult dose.
Powd for soln: Add 50 g of mafenide to 1000 mL of sterile water or NaCl 0.9% for irrigation to provide a 5% soln. Mix until dissolved.
Monitor acid-base balance, signs of infection and healing.
Description: Mafenide is a short-acting sulfonamide topical antibacterial agent that has a wide spectrum of activity. It has no definite mechanism of action, however, it appears to interfere w/ bacterial cellular metabolism. It has bacteriostatic action against many gm+ve and gm-ve organisms, including Pseudomonas aeruginosa and some anaerobes. Pharmacokinetics: Absorption: Absorbed systemically from burned surface. Time to peak plasma concentration: 2 -4 hr (cream). Metabolism: Metabolised to p-carboxybenzenesulfonamide, a weak carbonic anhydrase inhibitor. Excretion: Via urine, as metabolites.
Powd for soln: Store between 15-30°C. Cream: Store below 40°C. Protect from excessive heat.
D06BA03 - mafenide ; Belongs to the class of topical sulfonamides used in the treatment of dermatological diseases.
Anon. Mafenide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/07/2017.Buckingham R (ed). Mafenide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2017.Mafenide Acetate Powder, for Solution (Par Pharmaceutical Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/07/2017.McEvoy GK, Snow EK, Miller J et al (eds). Mafenide Acetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/07/2017.Sulfamylon Cream (Mylan Institutional Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/07/2017.