Not for treatment of cerebral malaria or other severe manifestations of complicated malaria eg, hyperparasitaemia, pulmonary oedema or renal failure. Recrudescent infections due to P falciparum
or failure of chemoprophylaxis; travellers w/ intense exposure to P vivax
or P ovale
& those who develop malaria caused by either of these parasites. Monitor parasitaemia in patients receiving metoclopramide or tetracycline. Not recommended w/ concomitant rifampicin or rifabutin. Severe renal impairment. Pregnancy. Not recommended during lactation. Paed patients <11 kg.